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Holly Soutter
Holly Soutter
Senior Group Leader, Biophysics, Broad Institute
Verified email at broadinstitute.org
Title
Cited by
Cited by
Year
Structural insight into allosteric modulation of protease-activated receptor 2
RKY Cheng, C Fiez-Vandal, O Schlenker, K Edman, B Aggeler, DG Brown, ...
Nature 545 (7652), 112-115, 2017
2402017
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent …
KL Lee, CM Ambler, DR Anderson, BP Boscoe, AG Bree, JI Brodfuehrer, ...
Journal of medicinal chemistry 60 (13), 5521-5542, 2017
1282017
Imidazo [1, 5-a] quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis
KH Kim, A Maderna, ME Schnute, M Hegen, S Mohan, J Miyashiro, L Lin, ...
Bioorganic & medicinal chemistry letters 21 (21), 6258-6263, 2011
1032011
Fragment‐based screen against HIV protease
AL Perryman, Q Zhang, HH Soutter, R Rosenfeld, DE McRee, AJ Olson, ...
Chemical biology & drug design 75 (3), 257-268, 2010
882010
Discovery of a potent BTK inhibitor with a novel binding mode by using parallel selections with a DNA‐encoded chemical library
JW Cuozzo, PA Centrella, D Gikunju, S Habeshian, CD Hupp, AD Keefe, ...
ChemBioChem 18 (9), 864-871, 2017
782017
Isoform-selective ATAD2 chemical probe with novel chemical structure and unusual mode of action
AE Fernández-Montalván, M Berger, B Kuropka, SJ Koo, V Badock, ...
ACS chemical biology 12 (11), 2730-2736, 2017
772017
Structure based design of non-natural peptidic macrocyclic Mcl-1 inhibitors
JW Johannes, S Bates, C Beigie, MA Belmonte, J Breen, S Cao, ...
ACS medicinal chemistry letters 8 (2), 239-244, 2017
722017
Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas aeruginosa Thymidylate Kinase: From Hit to Lead Generation
JY Choi, MS Plummer, J Starr, CR Desbonnet, H Soutter, J Chang, ...
Journal of medicinal chemistry 55 (2), 852-870, 2012
612012
Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology
HH Soutter, P Centrella, MA Clark, JW Cuozzo, CE Dumelin, MA Guie, ...
Proceedings of the National Academy of Sciences 113 (49), E7880-E7889, 2016
512016
Anti-IL-12/IL-23 antibodies and uses thereof
DW Borhani, R Sadhukhan, SE Lacy, HH Soutter
US Patent App. 13/374,693, 2012
492012
Agonists and antagonists of protease-activated receptor 2 discovered within a DNA-encoded chemical library using mutational stabilization of the target
DG Brown, GA Brown, P Centrella, K Certel, RM Cooke, JW Cuozzo, ...
SLAS DISCOVERY: Advancing the Science of Drug Discovery 23 (5), 429-436, 2018
432018
Discovery of a structural class of antibiotics with explainable deep learning
F Wong, EJ Zheng, JA Valeri, NM Donghia, MN Anahtar, S Omori, A Li, ...
Nature 626 (7997), 177-185, 2024
222024
Overview of recent progress in protein-expression technologies for small-molecule screening
JW Cuozzo, HH Soutter
Journal of Biomolecular Screening 19 (7), 1000-1013, 2014
112014
Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence
BK Allen, MM Kulkarni, B Chamberlain, T Dwight, C Koh, R Samant, ...
Biorxiv, 2022.05. 23.493001, 2022
102022
Discovery of clinical candidate PF-06650833: a potent, selective, and efficient inhibitor of IRAK4 from fragment-based drug design
K Lee, C Allais, C Ambler, D Anderson, B Boscoe, A Bree, J Brodfuehrer, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016
22016
DNA-encoded macrocyclic compound libraries for challenging targets
Y Zhang, A Keefe, P Centrella, J Cuozzo, H Soutter, D Resnicow, ...
Cancer Research 83 (7_Supplement), 5331-5331, 2023
2023
Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas aeruginosa Thymidylat
JY Choi, MS Plummer, J Starr, CR Desbonnet, H Soutter, J Chang, ...
J. Med. Chem. 55 (2)), 2021
2021
Abstract LB-A20: True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy
MM Kulkarni, T Dwight, K Marino, BK Allen, M Taimi, C Bastos, S Lai, ...
Molecular Cancer Therapeutics 18 (12_Supplement), LB-A20-LB-A20, 2019
2019
True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy
MM Kulkarni, T Dwight, K Marino, BK Allen, M Taimi, C Bastos, S Lai, ...
MOLECULAR CANCER THERAPEUTICS 18 (12), 2019
2019
Tackling challenging targets in innate immune pathways with integrated biophysics and simulation
H Soutter, I Kolossvary, K Marino, S Sparks, H Xu, W Sherman
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258, 2019
2019
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