Chengkai Dai
Chengkai Dai
National Institutes of Health/National Cancer Institute
Подтвержден адрес электронной почты в домене - Главная страница
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
EC Holland, J Celestino, C Dai, L Schaefer, RE Sawaya, GN Fuller
Nature genetics 25 (1), 55-57, 2000
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
C Dai, L Whitesell, AB Rogers, S Lindquist
Cell 130 (6), 1005-1018, 2007
PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
C Dai, JC Celestino, Y Okada, DN Louis, GN Fuller, EC Holland
Genes & development 15 (15), 1913-1925, 2001
Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt
L Uhrbom, C Dai, JC Celestino, MK Rosenblum, GN Fuller, EC Holland
Cancer research 62 (19), 5551-5558, 2002
Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis
AH Shih, C Dai, X Hu, MK Rosenblum, JA Koutcher, EC Holland
Cancer research 64 (14), 4783-4789, 2004
HSF1: guardian of proteostasis in cancer
C Dai, SB Sampson
Trends in cell biology 26 (1), 17-28, 2016
MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1
Z Tang, S Dai, Y He, RA Doty, LD Shultz, SB Sampson, C Dai
Cell 160 (4), 729-744, 2015
Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis
C Dai, S Santagata, Z Tang, J Shi, J Cao, H Kwon, RT Bronson, ...
The Journal of clinical investigation 122 (10), 3742-3754, 2012
Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27
N Gan, YC Wu, M Brunet, C Garrido, FL Chung, C Dai, L Mi
Journal of Biological Chemistry 285 (46), 35528-35536, 2010
Glioma models
C Dai, EC Holland
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1551 (1), M19-M27, 2001
p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13. 3
RM Wolf, N Draghi, X Liang, C Dai, L Uhrbom, C Eklöf, B Westermark, ...
Genes & development 17 (4), 476-487, 2003
Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo
EC Holland, Y Li, J Celestino, C Dai, L Schaefer, RA Sawaya, GN Fuller
The American journal of pathology 157 (3), 1031-1037, 2000
MYC expression promotes the proliferation of neural progenitor cells in culture and in vivo
D Fults, C Pedone, C Dai, EC Holland
Neoplasia 4 (1), 32-39, 2002
Suppression of the HSF 1‐mediated proteotoxic stress response by the metabolic stress sensor AMPK
S Dai, Z Tang, J Cao, W Zhou, H Li, S Sampson, C Dai
The EMBO journal 34 (3), 275-293, 2015
Proteotoxic stress of cancer: implication of the heat‐shock response in oncogenesis
C Dai, S Dai, J Cao
Journal of cellular physiology 227 (8), 2982-2987, 2012
The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats
C Dai, Y Lyustikman, A Shih, X Hu, GN Fuller, M Rosenblum, EC Holland
Neoplasia 7 (4), 397-406, 2005
HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth
KH Su, J Cao, Z Tang, S Dai, Y He, SB Sampson, IJ Benjamin, C Dai
Nature cell biology 18 (5), 527-539, 2016
Overexpression of c-MYC promotes an undifferentiated phenotype in cultured astrocytes and allows elevated Ras and Akt signaling to induce gliomas from GFAP-expressing cells in mice
AB Lassman, C Dai, GN Fuller, AJ Vickers, EC Holland
Neuron glia biology 1 (2), 157-163, 2004
Astrocyte differentiation states and glioma formation
C Dai, EC Holland
The Cancer Journal 9 (2), 72-81, 2003
HSP90: a rising star on the horizon of anticancer targets
L Whitesell, C Dai
Future Medicine Ltd 1 (4), 529-540, 2005
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