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Peter J Brown
Peter J Brown
Unknown affiliation
Verified email at mindspring.com
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Cited by
Year
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
SA Kliewer, SS Sundseth, SA Jones, PJ Brown, GB Wisely, CS Koble, ...
Proceedings of the National Academy of Sciences 94 (9), 4318-4323, 1997
27191997
The PPARs: from orphan receptors to drug discovery
TM Willson, PJ Brown, DD Sternbach, BR Henke
Journal of medicinal chemistry 43 (4), 527-550, 2000
24442000
Molecular recognition of fatty acids by peroxisome proliferator–activated receptors
HE Xu, MH Lambert, VG Montana, DJ Parks, SG Blanchard, PJ Brown, ...
Molecular cell 3 (3), 397-403, 1999
14921999
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
8322015
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ...
Nature chemical biology 7 (8), 566-574, 2011
5472011
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ...
ACS chemical biology 8 (6), 1324-1334, 2013
4782013
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ...
Nature communications 3 (1), 1288, 2012
2962012
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
F Grebien, M Vedadi, M Getlik, R Giambruno, A Grover, R Avellino, ...
Nature chemical biology 11 (8), 571-578, 2015
2782015
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
F Liu, D Barsyte-Lovejoy, F Li, Y Xiong, V Korboukh, XP Huang, ...
Journal of medicinal chemistry 56 (21), 8931-8942, 2013
2642013
Activation of peroxisome proliferator–activated receptor-α protects the heart from ischemia/reperfusion injury
T Yue, W Bao, BM Jucker, J Gu, AM Romanic, PJ Brown, J Cui, ...
Circulation 108 (19), 2393-2399, 2003
2642003
Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a
F Liu, X Chen, A Allali-Hassani, AM Quinn, GA Wasney, A Dong, ...
Journal of medicinal chemistry 52 (24), 7950-7953, 2009
2462009
A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases
MS Eram, Y Shen, MM Szewczyk, H Wu, G Senisterra, F Li, KV Butler, ...
ACS chemical biology 11 (3), 772-781, 2016
2302016
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2, 4-diamino-7-aminoalkoxy-quinazolines.
F Liu, X Chen, A Allali-Hassani, AM Quinn, TJ Wigle, GA Wasney, A Dong, ...
Journal of medicinal chemistry 53 (15), 5844-5857, 2010
2182010
Identification of a subtype selective human PPARα agonist through parallel-array synthesis
PJ Brown, LW Stuart, KP Hurley, MC Lewis, DA Winegar, JG Wilson, ...
Bioorganic & medicinal chemistry letters 11 (9), 1225-1227, 2001
2102001
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity
PJ Brown, DA Winegar, KD Plunket, LB Moore, MC Lewis, JG Wilson, ...
Journal of medicinal chemistry 42 (19), 3785-3788, 1999
1951999
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
LI James, D Barsyte-Lovejoy, N Zhong, L Krichevsky, VK Korboukh, ...
Nature chemical biology 9 (3), 184-191, 2013
1882013
Discovery and development of potent and selective inhibitors of histone methyltransferase g9a
RF Sweis, M Pliushchev, PJ Brown, J Guo, F Li, D Maag, AM Petros, ...
ACS medicinal chemistry letters 5 (2), 205-209, 2014
1852014
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
D Barsyte-Lovejoy, F Li, MJ Oudhoff, JH Tatlock, A Dong, H Zeng, H Wu, ...
Proceedings of the National Academy of Sciences 111 (35), 12853-12858, 2014
1812014
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5
G Senisterra, H Wu, A Allali-Hassani, GA Wasney, D Barsyte-Lovejoy, ...
Biochemical Journal 449 (1), 151-159, 2013
1622013
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines
F Liu, D Barsyte-Lovejoy, A Allali-Hassani, Y He, JM Herold, X Chen, ...
Journal of medicinal chemistry 54 (17), 6139-6150, 2011
1622011
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