| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 13140* | 2021 |
| Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease D Morgan, DM Diamond, PE Gottschall, KE Ugen, C Dickey, J Hardy, ... Nature 408 (6815), 982-985, 2000 | 2132 | 2000 |
| Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1 K Duff, C Eckman, C Zehr, X Yu, CM Prada, J Perez-Tur, M Hutton, L Buee, ... Nature 383 (6602), 710-713, 1996 | 2043 | 1996 |
| Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes L Holcomb, MN Gordon, E McGowan, X Yu, S Benkovic, P Jantzen, ... Nature medicine 4 (1), 97-100, 1998 | 1717 | 1998 |
| Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein J Lewis, E McGowan, J Rockwood, H Melrose, P Nacharaju, ... Nature genetics 25 (4), 402-405, 2000 | 1610 | 2000 |
| Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model LM Refolo, MA Pappolla, B Malester, J LaFrancois, T Bryant-Thomas, ... Neurobiology of disease 7 (4), 321-331, 2000 | 1321 | 2000 |
| Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease WH Yu, AM Cuervo, A Kumar, CM Peterhoff, SD Schmidt, JH Lee, ... The Journal of cell biology 171 (1), 87-98, 2005 | 1159 | 2005 |
| Trans-synaptic spread of tau pathology in vivo L Liu, V Drouet, JW Wu, MP Witter, SA Small, C Clelland, K Duff PloS one 7 (2), e31302, 2012 | 1134 | 2012 |
| Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo W Noble, E Planel, C Zehr, V Olm, J Meyerson, F Suleman, K Gaynor, ... Proceedings of the national academy of sciences 102 (19), 6990-6995, 2005 | 914 | 2005 |
| Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration CA Saura, SY Choi, V Beglopoulos, S Malkani, D Zhang, BSS Rao, ... Neuron 42 (1), 23-36, 2004 | 885 | 2004 |
| Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms C Andorfer, Y Kress, M Espinoza, R De Silva, KL Tucker, YA Barde, K Duff, ... Journal of neurochemistry 86 (3), 582-590, 2003 | 861 | 2003 |
| Linking Aβ and tau in late-onset Alzheimer's disease: a dual pathway hypothesis SA Small, K Duff Neuron 60 (4), 534-542, 2008 | 733 | 2008 |
| A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer's disease LM Refolo, MA Pappolla, J LaFrancois, B Malester, SD Schmidt, ... Neurobiology of disease 8 (5), 890-899, 2001 | 703 | 2001 |
| Neuronal activity enhances tau propagation and tau pathology in vivo JW Wu, SA Hussaini, IM Bastille, GA Rodriguez, A Mrejeru, K Rilett, ... Nature neuroscience 19 (8), 1085-1092, 2016 | 685 | 2016 |
| Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches J Tsai, J Grutzendler, K Duff, WB Gan Nature neuroscience 7 (11), 1181-1183, 2004 | 669 | 2004 |
| Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease UA Khan, L Liu, FA Provenzano, DE Berman, CP Profaci, R Sloan, ... Nature neuroscience 17 (2), 304-311, 2014 | 615 | 2014 |
| Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms C Andorfer, CM Acker, Y Kress, PR Hof, K Duff, P Davies Journal of Neuroscience 25 (22), 5446-5454, 2005 | 612 | 2005 |
| Comparative lipidomic analysis of mouse and human brain with Alzheimer disease RB Chan, TG Oliveira, EP Cortes, LS Honig, KE Duff, SA Small, MR Wenk, ... Journal of Biological Chemistry 287 (4), 2678-2688, 2012 | 584 | 2012 |
| Cdk5 is a key factor in tau aggregation and tangle formation in vivo W Noble, V Olm, K Takata, E Casey, O Mary, J Meyerson, K Gaynor, ... Neuron 38 (4), 555-565, 2003 | 581 | 2003 |
| Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons JW Wu, M Herman, L Liu, S Simoes, CM Acker, H Figueroa, JI Steinberg, ... Journal of Biological Chemistry 288 (3), 1856-1870, 2013 | 567 | 2013 |
