| Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1, 3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and … I Dijkgraaf, AY Rijnders, A Soede, AC Dechesne, GW van Esse, ... Organic & biomolecular chemistry 5 (6), 935-944, 2007 | 244 | 2007 |
| Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry DTS Rijkers, GW van Esse, R Merkx, AJ Brouwer, HJF Jacobs, RJ Pieters, ... Chemical communications, 4581-4583, 2005 | 136 | 2005 |
| Highly efficient coupling of β-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction R Merkx, AJ Brouwer, DTS Rijkers, RMJ Liskamp Organic Letters 7 (6), 1125-1128, 2005 | 109 | 2005 |
| High‐yielding microwave‐assisted synthesis of triazole‐linked glycodendrimers by copper‐catalyzed [3+ 2] cycloaddition JAF Joosten, NTH Tholen, F Ait El Maate, AJ Brouwer, GW Van Esse, ... European journal of organic chemistry 2005 (15), 3182-3185, 2005 | 102 | 2005 |
| Combinatorial chemistry for ligand development in catalysis: synthesis and catalysis screening of peptidosulfonamide tweezers on the solid phase AJ Brouwer, HJ van der Linden, RMJ Liskamp The Journal of Organic Chemistry 65 (6), 1750-1757, 2000 | 91 | 2000 |
| Synthesis of a novel amino acid based dendrimer SJE Mulders, AJ Brouwer, PGJ van der Meer, RMJ Liskamp Tetrahedron letters 38 (4), 631-634, 1997 | 77 | 1997 |
| Selective inhibition of the immunoproteasome by ligand‐induced crosslinking of the active site C Dubiella, H Cui, M Gersch, AJ Brouwer, SA Sieber, A Krüger, ... Angewandte Chemie International Edition 53 (44), 11969-11973, 2014 | 76 | 2014 |
| Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay O Vosyka, KR Vinothkumar, EV Wolf, AJ Brouwer, RMJ Liskamp, ... Proceedings of the National Academy of Sciences 110 (7), 2472-2477, 2013 | 74 | 2013 |
| Peptido sulfonyl fluorides as new powerful proteasome inhibitors AJ Brouwer, A Jonker, P Werkhoven, E Kuo, N Li, N Gallastegui, ... Journal of Medicinal Chemistry 55 (24), 10995-11003, 2012 | 73 | 2012 |
| Synthesis and catalytic application of amino acid based dendritic macromolecules RA Gossage, JTBH Jastrzebski, J Van Ameijde, SJE Mulders, AJ Brouwer, ... Tetrahedron letters 40 (7), 1413-1416, 1999 | 72 | 1999 |
| A practical solid phase synthesis of oligopeptidosulfonamide foldamers MCF Monnee, MF Marijne, AJ Brouwer, RMJ Liskamp Tetrahedron Letters 41 (41), 7991-7995, 2000 | 71 | 2000 |
| Molecular diversity of novel amino acid based dendrimers SJE Mulders, AJ Brouwer, RMJ Liskamp Tetrahedron letters 38 (17), 3085-3088, 1997 | 69 | 1997 |
| Tweezers with different bite: Increasing the affinity of synthetic receptors by varying the hinge part DWPM Löwik, MD Weingarten, M Broekema, AJ Brouwer, WC Still, ... Angewandte Chemie International Edition 37 (13‐14), 1846-1850, 1998 | 66 | 1998 |
| ‘Sulfo‐click’for ligation as well as for site‐specific conjugation with peptides, fluorophores, and metal chelators DTS Rijkers, R Merkx, CB Yim, AJ Brouwer, RMJ Liskamp Journal of Peptide Science: An Official Publication of the European Peptide …, 2010 | 63 | 2010 |
| Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap AJ Brouwer, T Ceylan, AM Jonker, T van der Linden, RMJ Liskamp Bioorganic & medicinal chemistry 19 (7), 2397-2406, 2011 | 50 | 2011 |
| Potent and highly selective inhibitors of the proteasome trypsin-like site by incorporation of basic side chain containing amino acid derived sulfonyl fluorides R Artschwager, DJ Ward, S Gannon, AJ Brouwer, H van de Langemheen, ... Journal of Medicinal Chemistry 61 (12), 5395-5411, 2018 | 49 | 2018 |
| Synthesis of β-aminoethanesulfonyl fluorides or 2-substituted taurine sulfonyl fluorides as potential protease inhibitors AJ Brouwer, T Ceylan, T van der Linden, RMJ Liskamp Tetrahedron Letters 50 (26), 3391-3393, 2009 | 48 | 2009 |
| Convergent synthesis and diversity of amino acid based dendrimers AJ Brouwer, SJE Mulders, RMJ Liskamp European Journal of Organic Chemistry 2001 (10), 1903-1915, 2001 | 48 | 2001 |
| An efficient synthesis of N-protected β-aminoethanesulfonyl chlorides: versatile building blocks for the synthesis of oligopeptidosulfonamides AJ Brouwer, MCF Monnee, RMJ Liskamp Synthesis 2000 (11), 1579-1584, 2000 | 48 | 2000 |
| Synthesis and structural investigations of N-alkylated β-peptidosulfonamide–peptide hybrids of the amyloidogenic amylin (20–29) sequence: implications of supramolecular folding … RC Elgersma, T Meijneke, R de Jong, AJ Brouwer, G Posthuma, ... Organic & Biomolecular Chemistry 4 (19), 3587-3597, 2006 | 47 | 2006 |
