Thomas M. Keck
Thomas M. Keck
Rowan University, Dept. Chemistry & Biochemistry, Dept. Molecular & Cellular Biosciences
Підтверджена електронна адреса в - Домашня сторінка
Identifying medication targets for psychostimulant addiction: unraveling the dopamine D3 receptor hypothesis
TM Keck, WS John, PW Czoty, MA Nader, AH Newman
Journal of medicinal chemistry 58 (14), 5361-5380, 2015
Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection
VR DeFilippis, B Robinson, TM Keck, SG Hansen, JA Nelson, KJ Früh
Journal of virology 80 (2), 1032-1037, 2006
Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid …
V Kumar, A Bonifazi, MP Ellenberger, TM Keck, E Pommier, R Rais, ...
Journal of medicinal chemistry 59 (16), 7634-7650, 2016
K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development
S Tiwari-Woodruff, L Beltran-Parrazal, A Charles, T Keck, T Vu, ...
American Journal of Physiology-Cell Physiology 291 (4), C687-C698, 2006
High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice
CA Boateng, OM Bakare, J Zhan, AK Banala, C Burzynski, E Pommier, ...
Journal of medicinal chemistry 58 (15), 6195-6213, 2015
Synthesis and pharmacological characterization of novel trans-cyclopropylmethyl-linked bivalent ligands that exhibit selectivity and allosteric pharmacology at the dopamine D3 …
V Kumar, AE Moritz, TM Keck, A Bonifazi, MP Ellenberger, CD Sibley, ...
Journal of medicinal chemistry 60 (4), 1478-1494, 2017
Beyond Small-Molecule SAR: Using the Dopamine D3 Receptor Crystal Structure to Guide Drug Design.
TM Keck, C Burzynski, L Shi, AH Newman
Advances in pharmacology (San Diego, Calif.) 69, 267-300, 2014
Tranylcypromine Substituted cis-Hydroxycyclobutylnaphthamides as Potent and Selective Dopamine D3 Receptor Antagonists
J Chen, B Levant, C Jiang, TM Keck, AH Newman, S Wang
Journal of medicinal chemistry 57 (11), 4962-4968, 2014
A novel mGluR5 antagonist, MFZ 10‐7, inhibits cocaine‐taking and cocaine‐seeking behavior in rats
TM Keck, MF Zou, GH Bi, HY Zhang, XF Wang, HJ Yang, R Srivastava, ...
Addiction Biology 19 (2), 195-209, 2014
Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor
M Michino, CA Boateng, P Donthamsetti, H Yano, OM Bakare, A Bonifazi, ...
Journal of medicinal chemistry 60 (2), 580-593, 2017
Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans
TM Keck, HJ Yang, GH Bi, Y Huang, HY Zhang, R Srivastava, EL Gardner, ...
Psychopharmacology 229 (2), 253-65, 2013
Dopamine D4 receptor deficiency in mice alters behavioral responses to anxiogenic stimuli and the psychostimulant methylphenidate
TM Keck, KL Suchland, CC Jimenez, DK Grandy
Pharmacology Biochemistry and Behavior 103 (4), 831–841, 2013
Novel Analogues of (R)-5-(Methylamino)-5, 6-dihydro-4 H-imidazo [4, 5, 1-ij] quinolin-2 (1 H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity
M Zou, TM Keck, V Kumar, P Donthamsetti, M Michino, C Burzynski, ...
Using click chemistry toward novel 1, 2, 3-triazole-linked dopamine D3 receptor ligands
TM Keck, AK Banala, RD Slack, C Burzynski, A Bonifazi, ...
Bioorganic & medicinal chemistry 23 (14), 4000-4012, 2015
Dopamine D4 Receptor-Selective Compounds Reveal Structure–Activity Relationships that Engender Agonist Efficacy
TM Keck, RB Free, MM Day, SL Brown, MS Maddaluna, G Fountain, ...
Journal of medicinal chemistry 62 (7), 3722-3740, 2019
The replacement of the 2-methoxy substituent of N-((6, 6-diphenyl-1, 4-dioxan-2-yl) methyl)-2-(2-methoxyphenoxy) ethan-1-amine improves the selectivity for 5-HT1A receptor over …
F Del Bello, A Bonifazi, M Giannella, G Giorgioni, A Piergentili, R Petrelli, ...
European journal of medicinal chemistry 125, 233-244, 2017
Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation
TM Keck, MF Zou, P Zhang, RP Rutledge, AH Newman
ACS medicinal chemistry letters 3 (7), 544-549, 2012
Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66
V Kumar, AK Banala, EG Garcia, J Cao, TM Keck, A Bonifazi, ...
ACS Medicinal Chemistry Letters 5 (6), 647–651, 2014
Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson’s Disease or …
F Del Bello, D Ambrosini, A Bonifazi, AH Newman, TM Keck, M Giannella, ...
ACS chemical neuroscience 10 (5), 2222-2228, 2019
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist
AE Moritz, RB Free, WS Weiner, EO Akano, D Gandhi, A Abramyan, ...
Journal of medicinal chemistry 63 (10), 5526-5567, 2020
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