Zhe Chen
Zhe Chen
Verified email at utsouthwestern.edu
Title
Cited by
Cited by
Year
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
SL Masters, A Dunne, SL Subramanian, RL Hull, GM Tannahill, FA Sharp, ...
Nature immunology 11 (10), 897-904, 2010
9912010
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
YNP Chen, MJ LaMarche, HM Chan, P Fekkes, J Garcia-Fortanet, ...
Nature 535 (7610), 148-152, 2016
2822016
Thioredoxin/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases
E Yoshihara, S Masaki, Y Matsuo, Z Chen, H Tian, J Yodoi
Frontiers in immunology 4, 514, 2014
1842014
Allosteric inhibition of SHP2: identification of a potent, selective, and orally efficacious phosphatase inhibitor
J Garcia Fortanet, CHT Chen, YNP Chen, Z Chen, Z Deng, B Firestone, ...
Journal of medicinal chemistry 59 (17), 7773-7782, 2016
932016
Gene expression profile of transgenic mouse kidney reveals pathogenesis of hepatitis B virus associated nephropathy
J Ren, L Wang, Z Chen, ZM Ma, HG Zhu, DL Yang, XY Li, BI Wang, J Fei, ...
Journal of medical virology 78 (5), 551-560, 2006
682006
Effect of glucagon-like peptide 2 on tight junction in jejunal epithelium of weaned pigs though MAPK signaling pathway
C Yu, G Jia, Y Jiang, Q Deng, Z Chen, Z Xu, X Chen, K Wang
Asian-Australasian Journal of Animal Sciences 27 (5), 733, 2014
64*2014
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function
M Gorski, PJ Van Der Most, A Teumer, AY Chu, M Li, V Mijatovic, IM Nolte, ...
Scientific reports 7, 45040, 2017
632017
Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits
A Teumer, Q Qi, M Nethander, H Aschard, S Bandinelli, M Beekman, ...
Aging cell 15 (5), 811-824, 2016
582016
Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus
H Masutani, E Yoshihara, S Masaki, Z Chen, J Yodoi
Journal of clinical biochemistry and nutrition, 1110240115-1110240115, 2011
552011
Thiol redox transitions by thioredoxin and thioredoxin-binding protein-2 in cell signaling
E Yoshihara, Z Chen, Y Matsuo, H Masutani, J Yodoi
Methods in enzymology 474, 67-82, 2010
552010
Real-time resolution of point mutations that cause phenovariance in mice
T Wang, X Zhan, CH Bu, S Lyon, D Pratt, S Hildebrand, JH Choi, Z Zhang, ...
Proceedings of the National Academy of Sciences 112 (5), E440-E449, 2015
432015
Dual allosteric inhibition of SHP2 phosphatase
M Fodor, E Price, P Wang, H Lu, A Argintaru, Z Chen, M Glick, HX Hao, ...
ACS Chemical Biology 13 (3), 647-656, 2018
242018
Differential roles of Annexin A1 (ANXA1/lipocortin-1/lipomodulin) and thioredoxin binding protein-2 (TBP-2/VDUP1/TXNIP) in glucocorticoid signaling of HTLV-I-transformed T cells
Z Chen, E Yoshihara, A Son, Y Matsuo, H Masutani, K Sugie, M Maeda, ...
Immunology letters 131 (1), 11-18, 2010
242010
Biomarkers
F Blackhall, S Peters, KM Kerr, K O'Byrne, H Hager, A Sejda, ...
Annals of Oncology 23 (suppl_9), ix73-ix94, 2012
232012
Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling
Z Chen, W Holland, JM Shelton, A Ali, X Zhan, S Won, W Tomisato, C Liu, ...
Proceedings of the National Academy of Sciences 111 (20), 7367-7372, 2014
222014
Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation
Z Chen, DA Lopez-Ramos, E Yoshihara, Y Maeda, H Masutani, K Sugie, ...
Leukemia 25 (3), 440-448, 2011
222011
Rare coding variants pinpoint genes that control human hematological traits
A Mousas, G Ntritsos, MH Chen, C Song, JE Huffman, I Tzoulaki, P Elliott, ...
PLoS genetics 13 (8), e1006925, 2017
182017
Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice
QM Zhu, KA Ko, S Ture, MA Mastrangelo, MH Chen, AD Johnson, ...
Arteriosclerosis, thrombosis, and vascular biology 37 (2), 264-270, 2017
172017
6-Amino-3-methylpyrimidinones as potent, selective, and orally efficacious SHP2 inhibitors
P Sarver, M Acker, JT Bagdanoff, Z Chen, YN Chen, H Chan, B Firestone, ...
Journal of medicinal chemistry 62 (4), 1793-1802, 2019
122019
Optimization of fused bicyclic allosteric SHP2 inhibitors
JT Bagdanoff, Z Chen, M Acker, YN Chen, H Chan, M Dore, B Firestone, ...
Journal of medicinal chemistry 62 (4), 1781-1792, 2019
122019
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