Cynthia Lemere
Cynthia Lemere
Brigham and Women's Hospital; Harvard Medical School
Підтверджена електронна адреса в
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
GM Shankar, S Li, TH Mehta, A Garcia-Munoz, NE Shepardson, I Smith, ...
Nature medicine 14 (8), 837-842, 2008
Complement and microglia mediate early synapse loss in Alzheimer mouse models
S Hong, VF Beja-Glasser, BM Nfonoyim, A Frouin, S Li, S Ramakrishnan, ...
Science 352 (6286), 712-716, 2016
The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases
S Krasemann, C Madore, R Cialic, C Baufeld, N Calcagno, R El Fatimy, ...
Immunity 47 (3), 566-581. e9, 2017
The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway
C Haass, CA Lemere, A Capell, M Citron, P Seubert, D Schenk, L Lannfelt, ...
Nature medicine 1 (12), 1291-1296, 1995
Sequence of deposition of heterogeneous amyloid β-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation
CA Lemere, JK Blusztajn, H Yamaguchi, T Wisniewski, TC Saido, ...
Neurobiology of disease 3 (1), 16-32, 1996
Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo
I Klyubin, DM Walsh, CA Lemere, WK Cullen, GM Shankar, V Betts, ...
Nature medicine 11 (5), 556-561, 2005
The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
CA Lemere, F LoPERA, KS Kosik, CL Lendon, J OssA, TC Saido, ...
Nature medicine 2 (10), 1146-1150, 1996
APP processing is regulated by cytoplasmic phosphorylation
MS Lee, SC Kao, CA Lemere, W Xia, HC Tseng, Y Zhou, R Neve, ...
The Journal of cell biology 163 (1), 83-95, 2003
Nasal administration of amyloid‐β peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease
HL Weiner, CA Lemere, R Maron, ET Spooner, TJ Grenfell, C Mori, ...
Annals of Neurology: Official Journal of the American Neurological …, 2000
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
RJ Bateman, PS Aisen, B De Strooper, NC Fox, CA Lemere, JM Ringman, ...
Alzheimer's research & therapy 3 (1), 1-13, 2011
Can Alzheimer disease be prevented by amyloid-β immunotherapy?
CA Lemere, E Masliah
Nature Reviews Neurology 6 (2), 108-119, 2010
Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice
P He, Z Zhong, K Lindholm, L Berning, W Lee, C Lemere, M Staufenbiel, ...
The Journal of cell biology 178 (5), 829-841, 2007
Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to β-amyloid
Y Matsuoka, M Saito, J LaFrancois, M Saito, K Gaynor, V Olm, L Wang, ...
Journal of Neuroscience 23 (1), 29-33, 2003
Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation
F Lopera, A Ardilla, A Martínez, L Madrigal, JC Arango-Viana, CA Lemere, ...
Jama 277 (10), 793-799, 1997
Amyloid β protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization
I Klyubin, V Betts, AT Welzel, K Blennow, H Zetterberg, A Wallin, ...
Journal of Neuroscience 28 (16), 4231-4237, 2008
Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer’s disease
Y Matsuoka, M Picciano, B Malester, J LaFrancois, C Zehr, ...
The American journal of pathology 158 (4), 1345-1354, 2001
Intraneuronal Aβ42 accumulation in Down syndrome brain
C Mori, ET Spooner, KE Wisniewski, TM Wisniewski, H Yamaguchi, ...
Amyloid 9 (2), 88-102, 2002
Complement C3 deficiency leads to accelerated amyloid β plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor …
M Maier, Y Peng, L Jiang, TJ Seabrook, MC Carroll, CA Lemere
Journal of Neuroscience 28 (25), 6333-6341, 2008
Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3β and cyclin-dependent kinase 5, a component …
H Yamaguchi, K Ishiguro, T Uchida, A Takashima, CA Lemere, K Imahori
Acta neuropathologica 92 (3), 232-241, 1996
The epigenetics of aging and neurodegeneration
R Lardenoije, A Iatrou, G Kenis, K Kompotis, HWM Steinbusch, ...
Progress in neurobiology 131, 21-64, 2015
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Статті 1–20