| Mapping the human genetic architecture of COVID-19 Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ... Nature 600 (7889), 472-477, 2021 | 715 | 2021 |
| Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension O Prysyazhna, O Rudyk, P Eaton Nature medicine 18 (2), 286-290, 2012 | 192 | 2012 |
| Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase RL Charles, O Rudyk, O Prysyazhna, A Kamynina, J Yang, C Morisseau, ... Proceedings of the National Academy of Sciences 111 (22), 8167-8172, 2014 | 108 | 2014 |
| Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide D Stubbert, O Prysyazhna, O Rudyk, J Scotcher, JR Burgoyne, P Eaton Hypertension 64 (6), 1344-1351, 2014 | 104 | 2014 |
| Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation CP Stanley, GJ Maghzal, A Ayer, J Talib, AM Giltrap, S Shengule, ... Nature 566 (7745), 548-552, 2019 | 96 | 2019 |
| cGMP-dependent activation of protein kinase G precludes disulfide activation: implications for blood pressure control JR Burgoyne, O Prysyazhna, O Rudyk, P Eaton Hypertension 60 (5), 1301-1308, 2012 | 91 | 2012 |
| Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy M Fernandez-Caggiano, A Kamynina, AA Francois, O Prysyazhna, ... Nature metabolism 2 (11), 1223-1231, 2020 | 76 | 2020 |
| Blood pressure–lowering by the antioxidant resveratrol is counterintuitively mediated by oxidation of cGMP-dependent protein kinase O Prysyazhna, K Wolhuter, C Switzer, C Santos, X Yang, S Lynham, ... Circulation 140 (2), 126-137, 2019 | 68 | 2019 |
| Protein kinase G oxidation is a major cause of injury during sepsis O Rudyk, A Phinikaridou, O Prysyazhna, JR Burgoyne, RM Botnar, ... Proceedings of the National Academy of Sciences 110 (24), 9909-9913, 2013 | 64 | 2013 |
| Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse O Rudyk, O Prysyazhna, JR Burgoyne, P Eaton Circulation 126 (3), 287-295, 2012 | 60 | 2012 |
| Distinct regulatory effects of myeloid cell and endothelial cell NAPDH oxidase 2 on blood pressure CM Sag, M Schnelle, J Zhang, CE Murdoch, S Kossmann, A Protti, ... Circulation 135 (22), 2163-2177, 2017 | 58 | 2017 |
| Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice JR Burgoyne, O Rudyk, H Cho, O Prysyazhna, N Hathaway, A Weeks, ... Nature communications 6 (1), 7920, 2015 | 53 | 2015 |
| Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response J Scotcher, O Prysyazhna, A Boguslavskyi, K Kistamas, N Hadgraft, ... Nature communications 7 (1), 13187, 2016 | 52 | 2016 |
| Phosphodiesterase 5 inhibition limits doxorubicin-induced heart failure by attenuating protein kinase G Iα oxidation O Prysyazhna, JR Burgoyne, J Scotcher, S Grover, D Kass, P Eaton Journal of Biological Chemistry 291 (33), 17427-17436, 2016 | 51 | 2016 |
| Transcriptional regulation of cystathionine-γ-lyase in endothelial cells by NADPH oxidase 4-dependent signaling RK Mistry, TVA Murray, O Prysyazhna, D Martin, JR Burgoyne, C Santos, ... Journal of Biological Chemistry 291 (4), 1774-1788, 2016 | 51 | 2016 |
| Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling M Feelisch, T Akaike, K Griffiths, T Ida, O Prysyazhna, JJ Goodwin, ... Cardiovascular Research 116 (1), 51-62, 2020 | 43 | 2020 |
| Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation S Akashi, KA Ahmed, T Sawa, K Ono, H Tsutsuki, JR Burgoyne, T Ida, ... Biochemistry 55 (5), 751-761, 2016 | 30 | 2016 |
| Analysis of mitochondrial proteins in the surviving myocardium after ischemia identifies mitochondrial pyruvate carrier expression as possible mediator of tissue viability M Fernández-Caggiano, O Prysyazhna, J Barallobre-Barreiro, ... Molecular & Cellular Proteomics 15 (1), 246-255, 2016 | 30 | 2016 |
| Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system O Prysyazhna, P Eaton Frontiers in pharmacology 6, 136149, 2015 | 28 | 2015 |
| Proof of principle for a novel class of antihypertensives that target the oxidative activation of PKG Iα (protein kinase G Iα) JR Burgoyne, O Prysyazhna, DA Richards, P Eaton Hypertension 70 (3), 577-586, 2017 | 26 | 2017 |
Olena RudykLecturer, Principal InvestigatorПодтвержден адрес электронной почты в домене kcl.ac.uk
