| Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease S Jawhar, A Trawicka, C Jenneckens, TA Bayer, O Wirths Neurobiology of aging 33 (1), 196. e29-196. e40, 2012 | 580 | 2012 |
| Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Aβ42 accumulation in a novel Alzheimer transgenic model C Casas, N Sergeant, JM Itier, V Blanchard, O Wirths, N Van Der Kolk, ... The American journal of pathology 165 (4), 1289-1300, 2004 | 537 | 2004 |
| A modified β‐amyloid hypothesis: intraneuronal accumulation of the β‐amyloid peptide–the first step of a fatal cascade O Wirths, G Multhaup, TA Bayer Journal of neurochemistry 91 (3), 513-520, 2004 | 517 | 2004 |
| Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice O Wirths, G Multhaup, C Czech, V Blanchard, S Moussaoui, G Tremp, ... Neuroscience letters 306 (1-2), 116-120, 2001 | 421 | 2001 |
| Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease C Schmitz, BPF Rutten, A Pielen, S Schäfer, O Wirths, G Tremp, C Czech, ... The American journal of pathology 164 (4), 1495-1502, 2004 | 379 | 2004 |
| Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice V Blanchard, S Moussaoui, C Czech, N Touchet, B Bonici, M Planche, ... Experimental neurology 184 (1), 247-263, 2003 | 352 | 2003 |
| Intracellular accumulation of amyloid-Beta-a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease TA Bayer, O Wirths Frontiers in aging neuroscience 2, 1359, 2010 | 290 | 2010 |
| Key factors in Alzheimer's disease: β‐amyloid precursor protein processing, metabolism and intraneuronal transport TA Bayer, O Wirths, K Majtényi, T Hartmann, G Multhaup, K Beyreuther, ... Brain Pathology 11 (1), 1-11, 2001 | 259 | 2001 |
| Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer disease S Jawhar, O Wirths, TA Bayer Journal of Biological Chemistry 286 (45), 38825-38832, 2011 | 246 | 2011 |
| Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model O Wirths, H Breyhan, H Cynis, S Schilling, HU Demuth, TA Bayer Acta neuropathologica 118, 487-496, 2009 | 209 | 2009 |
| N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits Y Bouter, K Dietrich, JL Wittnam, N Rezaei-Ghaleh, T Pillot, ... Acta neuropathologica 126, 189-205, 2013 | 196 | 2013 |
| Overexpression of human Dickkopf-1, an antagonist of wingless/WNT signaling, in human hepatoblastomas and Wilms’ tumors O Wirths, A Waha, S Weggen, P Schirmacher, T Kühne, CG Goodyer, ... Laboratory investigation 83 (3), 429-434, 2003 | 187 | 2003 |
| Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer’s disease TA Bayer, O Wirths Acta neuropathologica 127, 787-801, 2014 | 173 | 2014 |
| Intraneuronal APP/Aβ Trafficking and Plaque Formation in β‐Amyloid Precursor Protein and Presenilin‐1 Transgenic Mice O Wirths, G Multhaup, C Czech, N Feldmann, V Blanchard, G Tremp, ... Brain Pathology 12 (3), 275-286, 2002 | 157 | 2002 |
| Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein V Venkataramani, C Rossner, L Iffland, S Schweyer, IY Tamboli, J Walter, ... Journal of biological chemistry 285 (14), 10678-10689, 2010 | 152 | 2010 |
| Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice DZ Christensen, SL Kraus, A Flohr, MC Cotel, O Wirths, TA Bayer Acta neuropathologica 116, 647-655, 2008 | 152 | 2008 |
| Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer’s disease O Wirths, J Weis, J Szczygielski, G Multhaup, TA Bayer Acta neuropathologica 111, 312-319, 2006 | 152 | 2006 |
| Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease O Wirths, H Breyhan, A Marcello, MC Cotel, W Brück, TA Bayer Neurobiology of aging 31 (5), 747-757, 2010 | 151 | 2010 |
| Age-dependent axonal degeneration in an Alzheimer mouse model O Wirths, J Weis, R Kayed, TC Saido, TA Bayer Neurobiology of aging 28 (11), 1689-1699, 2007 | 146 | 2007 |
| Identification of low molecular weight pyroglutamate Aβ oligomers in Alzheimer disease: a novel tool for therapy and diagnosis O Wirths, C Erck, H Martens, A Harmeier, C Geumann, S Jawhar, S Kumar, ... Journal of biological chemistry 285 (53), 41517-41524, 2010 | 135 | 2010 |
