| Mechanisms of action of ribavirin against distinct viruses JD Graci, CE Cameron Reviews in medical virology 16 (1), 37-48, 2006 | 615 | 2006 |
| Quasispecies, error catastrophe, and the antiviral activity of ribavirin JD Graci, CE Cameron Virology 298 (2), 175-180, 2002 | 164 | 2002 |
| RNA virus population diversity, an optimum for maximal fitness and virulence VK Korboukh, CA Lee, A Acevedo, M Vignuzzi, Y Xiao, JJ Arnold, ... Journal of Biological Chemistry 289 (43), 29531-29544, 2014 | 114 | 2014 |
| Therapeutically targeting RNA viruses via lethal mutagenesis JD Graci, CE Cameron Future Medicine 3 (6), 553-566, 2008 | 89 | 2008 |
| Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis JD Graci, NF Gnädig, JE Galarraga, C Castro, M Vignuzzi, CE Cameron Journal of virology 86 (5), 2869-2873, 2012 | 76 | 2012 |
| Targeting of hematologic malignancies with PTC299, a novel potent inhibitor of dihydroorotate dehydrogenase with favorable pharmaceutical properties L Cao, M Weetall, C Trotta, K Cintron, J Ma, MJ Kim, B Furia, C Romfo, ... Molecular cancer therapeutics 18 (1), 3-16, 2019 | 75 | 2019 |
| The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines J Luban, RA Sattler, E Mühlberger, JD Graci, L Cao, M Weetall, C Trotta, ... Virus research 292, 198246, 2021 | 71 | 2021 |
| Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues JD Graci, K Too, ED Smidansky, JP Edathil, EW Barr, DA Harki, ... Antimicrobial agents and chemotherapy 52 (3), 971-979, 2008 | 64 | 2008 |
| Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases DA Harki, JD Graci, JE Galarraga, WJ Chain, CE Cameron, BR Peterson Journal of medicinal chemistry 49 (21), 6166-6169, 2006 | 61 | 2006 |
| Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue JD Graci, DA Harki, VS Korneeva, JP Edathil, K Too, D Franco, ... Journal of virology 81 (20), 11256-11266, 2007 | 57 | 2007 |
| Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-β-d-ribofuranosyl-3-nitropyrrole DA Harki, JD Graci, VS Korneeva, SKB Ghosh, Z Hong, CE Cameron, ... Biochemistry 41 (29), 9026-9033, 2002 | 55 | 2002 |
| Structure–activity relationship (SAR) optimization of 6-(indol-2-yl) pyridine-3-sulfonamides: identification of potent, selective, and orally bioavailable small molecules … N Zhang, X Zhang, J Zhu, A Turpoff, G Chen, C Morrill, S Huang, ... Journal of Medicinal Chemistry 57 (5), 2121-2135, 2014 | 54 | 2014 |
| High-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor S Micheva-Viteva, Y Kobayashi, LC Edelstein, AL Pacchia, HLR Lee, ... Journal of Biological Chemistry 286 (24), 21083-21091, 2011 | 48 | 2011 |
| Small molecule splicing modifiers with systemic HTT-lowering activity A Bhattacharyya, CR Trotta, J Narasimhan, KJ Wiedinger, W Li, ... Nature communications 12 (1), 7299, 2021 | 47 | 2021 |
| Challenges for the development of ribonucleoside analogues as inducers of error catastrophe JD Graci, CE Cameron Antiviral Chemistry and Chemotherapy 15 (1), 1-13, 2004 | 45 | 2004 |
| Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl) pyridine-3-sulfonamides targeting hepatitis C virus NS4B X Zhang, N Zhang, G Chen, A Turpoff, H Ren, J Takasugi, C Morrill, J Zhu, ... Bioorganic & medicinal chemistry letters 23 (13), 3947-3953, 2013 | 39 | 2013 |
| Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity K Moriyama, T Suzuki, K Negishi, JD Graci, CN Thompson, CE Cameron, ... Journal of medicinal chemistry 51 (1), 159-166, 2008 | 38 | 2008 |
| Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase DA Harki, JD Graci, JP Edathil, C Castro, CE Cameron, BR Peterson Chembiochem: a European journal of chemical biology 8 (12), 1359, 2007 | 29 | 2007 |
| Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C virus NS4B protein Z Gu, JD Graci, FC Lahser, JJ Breslin, SP Jung, JH Crona, P McMonagle, ... Antimicrobial agents and chemotherapy 57 (7), 3250-3261, 2013 | 23 | 2013 |
| 6-(Azaindol-2-yl) pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B G Chen, H Ren, N Zhang, W Lennox, A Turpoff, S Paget, C Li, N Almstead, ... Bioorganic & Medicinal Chemistry Letters 25 (4), 781-786, 2015 | 18 | 2015 |
