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Jonathan Kotula
Jonathan Kotula
Synlogic
Подтвержден адрес электронной почты в домене synlogictx.com - Главная страница
Название
Процитировано
Процитировано
Год
Programmable bacteria detect and record an environmental signal in the mammalian gut
JW Kotula, SJ Kerns, LA Shaket, L Siraj, JJ Collins, JC Way, PA Silver
Proceedings of the National Academy of Sciences 111 (13), 4838-4843, 2014
4092014
Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
DT Riglar, TW Giessen, M Baym, SJ Kerns, MJ Niederhuber, RT Bronson, ...
Nature biotechnology 35 (7), 653-658, 2017
3382017
An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans
CB Kurtz, YA Millet, MK Puurunen, M Perreault, MR Charbonneau, ...
Science translational medicine 11 (475), eaau7975, 2019
2802019
Aptamer-mediated delivery of splice-switching oligonucleotides to the nuclei of cancer cells
JW Kotula, ED Pratico, X Ming, O Nakagawa, RL Juliano, BA Sullenger
Nucleic acid therapeutics 22 (3), 187-195, 2012
1302012
A distributed cell division counter reveals growth dynamics in the gut microbiota
C Myhrvold, JW Kotula, WM Hicks, NJ Conway, PA Silver
Nature communications 6 (1), 10039, 2015
562015
Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth
JW Kotula, J Sun, M Li, ED Pratico, MP Fereshteh, DP Ahrens, ...
PLoS One 9 (4), e93441, 2014
472014
Bacteria engineered to treat diseases associated with hyperammonemia
D Falb, VM Isabella, JW Kotula, PF Miller, S Machinani
US Patent 9,688,967, 2017
362017
Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier
D Falb, VM Isabella, JW Kotula, PF Miller
US Patent App. 14/998,376, 2016
332016
Translational Development of Microbiome‐Based Therapeutics: Kinetics of E. coli Nissle and Engineered Strains in Humans and Nonhuman Primates
C Kurtz, WS Denney, L Blankstein, SE Guilmain, S Machinani, J Kotula, ...
Clinical and translational science 11 (2), 200-207, 2018
292018
Repeated measures of blood and breath ammonia in response to control, moderate and high protein dose in healthy men
LA Spacek, A Strzepka, S Saha, J Kotula, J Gelb, S Guilmain, T Risby, ...
Scientific reports 8 (1), 2554, 2018
252018
Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier
D Falb, VM Isabella, JW Kotula, PF Miller, Y Millet, A Fisher
US Patent 11,384,359, 2022
222022
Bacteria engineered to treat metabolic diseases
D Falb, VM Isabella, JW Kotula, PF Miller, R Sarah, Y Millet, A Fisher
US Patent 11,291,693, 2022
192022
Bacteria engineered to treat disorders involving the catabolism of a branched chain amino acid
D Falb, PF Miller, Y Millet, VM Isabella, JW Kotula, A Tucker
US Patent App. 15/379,445, 2017
192017
Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier
D Falb, VM Isabella, JW Kotula, PF Miller
US Patent 10,273,489, 2019
142019
Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
D Falb, JW Kotula, VM Isabella, PF Miller, S Machinani, S Saha, AB Fisher, ...
US Patent 11,723,932, 2023
132023
Bacteria engineered to reduce hyperphenylalaninemia
D Falb, VM Isabella, JW Kotula, PF Miller, Y Millet, R Sarah
US Patent 10,610,546, 2020
132020
Bacteria engineered to treat a disease or disorder
D Falb, PF Miller, JW Kotula, VM Isabella, S Machinani, AB Fisher, Y Millet
US Patent 9,889,164, 2018
112018
Bacteria engineered to treat disorders involving propionate catabolism
D Falb, P Miller, A Tucker, J Kotula, V ISABELLA, Y Millet
102017
Bacteria engineered to treat diseases associated with hyperammonemia
D Falb, VM Isabella, JW Kotula, PF Miller, S Machinani
US Patent 11,060,073, 2021
92021
Bacteria engineered to treat a disease or disorder
D Falb, PF Miller, JW Kotula, VM Isabella, S Machinani, AB Fisher, Y Millet
US Patent 10,933,102, 2021
92021
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