| Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo R Zufferey, D Nagy, RJ Mandel, L Naldini, D Trono Nature biotechnology 15 (9), 871-875, 1997 | 2503 | 1997 |
| Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery R Zufferey, T Dull, RJ Mandel, A Bukovsky, D Quiroz, L Naldini, D Trono Journal of virology 72 (12), 9873-9880, 1998 | 2442 | 1998 |
| Nucleus basalis and thalamic control of neocortical activity in the freely moving rat GY Buzsaki, RG Bickford, G Ponomareff, LJ Thal, R Mandel, FH Gage Journal of neuroscience 8 (11), 4007-4026, 1988 | 1086 | 1988 |
| Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of … C Burger, OS Gorbatyuk, MJ Velardo, CS Peden, P Williams, S Zolotukhin, ... Molecular Therapy 10 (2), 302-317, 2004 | 902 | 2004 |
| Parkinson-like neurodegeneration induced by targeted overexpression of α-synuclein in the nigrostriatal system D Kirik, C Rosenblad, C Burger, C Lundberg, TE Johansen, N Muzyczka, ... Journal of Neuroscience 22 (7), 2780-2791, 2002 | 894 | 2002 |
| Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned … D Kirik, C Rosenblad, A Björklund, RJ Mandel Journal of Neuroscience 20 (12), 4686-4700, 2000 | 490 | 2000 |
| Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: a new primate model of Parkinson's disease D Kirik, LE Annett, C Burger, N Muzyczka, RJ Mandel, A Björklund Proceedings of the National Academy of Sciences 100 (5), 2884-2889, 2003 | 487 | 2003 |
| Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data HC Fung, S Scholz, M Matarin, J Simón-Sánchez, D Hernandez, A Britton, ... The Lancet Neurology 5 (11), 911-916, 2006 | 468 | 2006 |
| Towards a neuroprotective gene therapy for Parkinson’s disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat … A Björklund, D Kirik, C Rosenblad, B Georgievska, C Lundberg, ... Brain research 886 (1-2), 82-98, 2000 | 430 | 2000 |
| Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine … RJ Mandel, SK Spratt, RO Snyder, SE Leff Proceedings of the National Academy of Sciences 94 (25), 14083-14088, 1997 | 429 | 1997 |
| The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease OS Gorbatyuk, S Li, LF Sullivan, W Chen, G Kondrikova, FP Manfredsson, ... Proceedings of the National Academy of Sciences 105 (2), 763-768, 2008 | 369 | 2008 |
| Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice E Rodriguez-Lebron, EM Denovan-Wright, K Nash, AS Lewin, RJ Mandel Molecular therapy 12 (4), 618-633, 2005 | 327 | 2005 |
| Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of … RJ Mandel, KG Rendahl, SK Spratt, RO Snyder, LK Cohen, SE Leff Journal of Neuroscience 18 (11), 4271-4284, 1998 | 279 | 1998 |
| Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat MA Cenci, P Kalén, RJ Mandel, A Björklund Brain research 581 (2), 217-228, 1992 | 272 | 1992 |
| Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral … A Eslamboli, B Georgievska, RM Ridley, HF Baker, N Muzyczka, C Burger, ... Journal of Neuroscience 25 (4), 769-777, 2005 | 271 | 2005 |
| Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain CS Peden, C Burger, N Muzyczka, RJ Mandel Journal of virology 78 (12), 6344-6359, 2004 | 251 | 2004 |
| Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease E Rogaeva, J Johnson, AE Lang, C Gulick, K Gwinn-Hardy, T Kawarai, ... Archives of neurology 61 (12), 1898-1904, 2004 | 250 | 2004 |
| Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain A Eslamboli, M Romero-Ramos, C Burger, T Bjorklund, N Muzyczka, ... Brain 130 (3), 799-815, 2007 | 245 | 2007 |
| In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degeneration OS Gorbatyuk, S Li, K Nash, M Gorbatyuk, AS Lewin, LF Sullivan, ... Molecular Therapy 18 (8), 1450-1457, 2010 | 235 | 2010 |
| Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of … PR Lowenstein, RJ Mandel, W Xiong, K Kroeger, MG Castro Current gene therapy 7 (5), 347-360, 2007 | 189 | 2007 |
