| AGC kinases, mechanisms of regulation and innovative drug development AE Leroux, JO Schulze, RM Biondi Seminars in cancer biology 48, 1-17, 2018 | 124 | 2018 |
| Low-molecular-mass antioxidants in parasites RL Krauth-Siegel, AE Leroux Antioxidants & redox signaling 17 (4), 583-607, 2012 | 115 | 2012 |
| Thiol redox biology of trypanosomatids and potential targets for chemotherapy AE Leroux, RL Krauth-Siegel Molecular and Biochemical Parasitology 206 (1-2), 67-74, 2016 | 111 | 2016 |
| Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei S Zimmermann, M Oufir, A Leroux, RL Krauth-Siegel, K Becker, M Kaiser, ... Bioorganic & medicinal chemistry 21 (22), 7202-7209, 2013 | 43 | 2013 |
| Functional characterization of NADP-dependent isocitrate dehydrogenase isozymes from Trypanosoma cruzi AE Leroux, DA Maugeri, JJ Cazzulo, C Nowicki Molecular and biochemical parasitology 177 (1), 61-64, 2011 | 42 | 2011 |
| Renaissance of allostery to disrupt protein kinase interactions AE Leroux, RM Biondi Trends in Biochemical Sciences 45 (1), 27-41, 2020 | 40 | 2020 |
| Comparative studies on the biochemical properties of the malic enzymes from Trypanosoma cruzi and Trypanosoma brucei AE Leroux, DA Maugeri, FR Opperdoes, JJ Cazzulo, C Nowicki FEMS microbiology letters 314 (1), 25-33, 2011 | 34 | 2011 |
| ACE2, the receptor that enables infection by SARS‐CoV‐2: biochemistry, structure, allostery and evaluation of the potential development of ACE2 modulators LZF Gross, M Sacerdoti, A Piiper, S Zeuzem, AE Leroux, RM Biondi ChemMedChem 15 (18), 1682-1690, 2020 | 33 | 2020 |
| Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling AE Leroux, JR Haanstra, BM Bakker, RL Krauth-Siegel Journal of Biological Chemistry 288 (33), 23751-23764, 2013 | 33 | 2013 |
| Functional characterization and subcellular localization of the three malate dehydrogenase isozymes in Leishmania spp. A Leroux, X Fleming-Canepa, A Aranda, D Maugeri, JJ Cazzulo, ... Molecular and biochemical parasitology 149 (1), 74-85, 2006 | 28 | 2006 |
| An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone RB Currier, K Ulrich, AE Leroux, N Dirdjaja, M Deambrosi, M Bonilla, ... PLoS Pathogens 15 (9), e1008065, 2019 | 17 | 2019 |
| Molecular and functional characterization of two malic enzymes from Leishmania parasites L Giordana, MH Sosa, AE Leroux, EFR Mendoza, P Petray, C Nowicki Molecular and biochemical parasitology 219, 67-76, 2018 | 10 | 2018 |
| The silicon trypanosome: a test case of iterative model extension in systems biology F Achcar, A Fadda, JR Haanstra, EJ Kerkhoven, DH Kim, AE Leroux, ... Advances in microbial physiology 64, 115-143, 2014 | 8 | 2014 |
| Allosteric regulation of protein kinases downstream of PI3-kinase signalling AE Leroux, LZF Gross, M Sacerdoti, RM Biondi Protein Allostery in Drug Discovery, 279-311, 2019 | 4 | 2019 |
| Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein M Sacerdoti, LZF Gross, AM Riley, K Zehnder, A Ghode, S Klinke, ... Science signaling 16 (789), eadd3184, 2023 | 3 | 2023 |
| The PB1 and the ZZ domain of the autophagy receptor p62/SQSTM1 regulate the interaction of p62/SQSTM1 with the autophagosome protein LC3B L Alcober‐Boquet, T Zang, L Pietsch, E Suess, M Hartmann, E Proschak, ... Protein Science, e4840, 2023 | | 2023 |
| The choreography of protein kinase PDK1 and its diverse substrate dance partners AE Leroux, RM Biondi Biochemical Journal 480 (19), 1503-1532, 2023 | | 2023 |
| ALLOSTERY to DISRUPT PROTEIN-PROTEIN INTERACTIONS with SMALL MOLECULES AE Leroux, M Sacerdoti, LZF Gross, M Acevedo, RM Biondi Biocell, 184-184, 2023 | | 2023 |
| Chemical biology and structural studies on the mechanism of regulation of phosphoinositide-dependent protein kinase 1 (PDK1) LZF Gross, M Sacerdoti, AE Leroux, A Ghode, GS Anand, JO Schulze, ... Acta Crystallographica Section A: Foundations and Advances 77, C1114-C1114, 2021 | | 2021 |
| A Chemical Biology Approach to Understand The Regulation Of Full-Length Phosphoinositide-Dependent Protein Kinase 1 (Pdk1) LZF Gross, M Sacerdoti, AE Leroux, JJ Rinaldi, MV Capellari, ... Biocell, 2019 | | 2019 |
Ricardo M. BiondiIBioBA, Buenos Aires, ArgentinaVerified email at med.uni-frankfurt.de
