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ashraf brik
ashraf brik
Professor of Chemistry
Подтвержден адрес электронной почты в домене technion.ac.il - Главная страница
Название
Процитировано
Процитировано
Год
HIV-1 protease: mechanism and drug discovery
A Brik, CH Wong
Organic & biomolecular chemistry 1 (1), 5-14, 2003
6552003
Small molecules targeting severe acute respiratory syndrome human coronavirus
CY Wu, JT Jan, SH Ma, CJ Kuo, HF Juan, YSE Cheng, HH Hsu, ...
Proceedings of the National Academy of Sciences 101 (27), 10012-10017, 2004
6322004
1, 2, 3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors
A Brik, J Alexandratos, YC Lin, JH Elder, AJ Olson, A Wlodawer, ...
ChemBioChem 6 (7), 1167-1168, 2005
3822005
Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins
S Bondalapati, M Jbara, A Brik
Nature chemistry 8 (5), 407-418, 2016
3102016
A copper (I)-catalyzed 1, 2, 3-triazole azide− alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant
MJ Giffin, H Heaslet, A Brik, YC Lin, G Cauvi, CH Wong, DE McRee, ...
Journal of medicinal chemistry 51 (20), 6263-6270, 2008
2792008
Highly efficient and chemoselective peptide ubiquitylation
KS Ajish Kumar, M Haj-Yahya, D Olschewski, HA Lashuel, A Brik
Angewandte Chemie (International ed. in English) 48 (43), 8090-4, 2009
2702009
Structural basis for histone H2B deubiquitination by the SAGA DUB module
MT Morgan, M Haj-Yahya, AE Ringel, P Bandi, A Brik, C Wolberger
Science 351 (6274), 725-728, 2016
2442016
Total chemical synthesis of a 304 amino acid K48‐linked tetraubiquitin protein
KSA Kumar, SN Bavikar, L Spasser, T Moyal, S Ohayon, A Brik
Angewandte Chemie International Edition 27 (50), 6137-6141, 2011
2402011
RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation
G Fuchs, E Shema, R Vesterman, E Kotler, Z Wolchinsky, S Wilder, ...
Molecular cell 46 (5), 662-673, 2012
2162012
Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors
A Brik, J Muldoon, YC Lin, JH Elder, DS Goodsell, AJ Olson, VV Fokin, ...
ChemBioChem 4 (11), 1246-1248, 2003
2142003
The size of the proteasomal substrate determines whether its degradation will be mediated by mono-or polyubiquitylation
N Shabek, Y Herman-Bachinsky, S Buchsbaum, O Lewinson, ...
Molecular cell 48 (1), 87-97, 2012
1902012
Total chemical synthesis of di‐ubiquitin chains
KSA Kumar, L Spasser, LA Erlich, SN Bavikar, A Brik
Angewandte Chemie International Edition 48 (49), 9126-9131, 2010
1872010
Protein synthesis assisted by native chemical ligation at leucine
Z Harpaz, P Siman, KSA Kumar, A Brik
ChemBioChem 11 (9), 1232-1235, 2010
1672010
Sugar-assisted glycopeptide ligation
A Brik, YY Yang, S Ficht, CH Wong
Journal of the American Chemical Society 128 (17), 5626-5627, 2006
1582006
Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology
M Haj-Yahya, B Fauvet, Y Herman-Bachinsky, M Hejjaoui, SN Bavikar, ...
Proceedings of the National Academy of Sciences 110 (44), 17726-17731, 2013
1472013
Chemistry and biology of the ubiquitin signal
L Spasser, A Brik
Angewandte Chemie International Edition 51 (28), 6840-6862, 2012
1442012
Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34.
P Siman, SV Karthikeyan, M Nikolov, W Fischle, A Brik
Angewandte Chemie-International Edition 52 (31), 8059-8063, 2013
1392013
Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein
M Hejjaoui, M Haj-Yahya, K KS, A Brik, HA Lashuel
Angewandte Chemie International Edition 50 (2), 405-409, 2011
1372011
Palladium in the chemical synthesis and modification of proteins
M Jbara, SK Maity, A Brik
Angewandte Chemie International Edition 56 (36), 10644-10655, 2017
1342017
Self-recognition mechanism of MamA, a magnetosome-associated TPR-containing protein, promotes complex assembly
N Zeytuni, E Ozyamak, K Ben-Harush, G Davidov, M Levin, Y Gat, T Moyal, ...
Proceedings of the National Academy of Sciences 108 (33), E480-E487, 2011
1312011
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Статьи 1–20