| The regulation of biofilm development by quorum sensing in Aeromonas hydrophila MJ Lynch, S Swift, DF Kirke, CW Keevil, CER Dodd, P Williams Environmental microbiology 4 (1), 18-28, 2002 | 449 | 2002 |
| Quorum Sensing-Dependent Regulation and Blockade of Exoprotease Production in Aeromonas hydrophila S Swift, MJ Lynch, L Fish, DF Kirke, JM Tomás, GSAB Stewart, P Williams Infection and immunity 67 (10), 5192-5199, 1999 | 360 | 1999 |
| RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with βarrestin to control the protein kinase A/AKAP79-mediated switching of the … MJ Lynch, GS Baillie, A Mohamed, X Li, C Maisonneuve, E Klussmann, ... Journal of Biological Chemistry 280 (39), 33178-33189, 2005 | 242 | 2005 |
| PGE1 stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases A Terrin, G Di Benedetto, V Pertegato, YF Cheung, G Baillie, MJ Lynch, ... The Journal of cell biology 175 (3), 441-451, 2006 | 209 | 2006 |
| Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, β-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5 GB Bolger, GS Baillie, X Li, MJ Lynch, P Herzyk, A Mohamed, ... Biochemical Journal 398 (1), 23-36, 2006 | 173 | 2006 |
| p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway BD Sachs, GS Baillie, JR McCall, MA Passino, C Schachtrup, DA Wallace, ... The Journal of cell biology 177 (6), 1119-1132, 2007 | 146 | 2007 |
| EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation E Huston, MJ Lynch, A Mohamed, DM Collins, EV Hill, R MacLeod, ... Proceedings of the National Academy of Sciences 105 (35), 12791-12796, 2008 | 138 | 2008 |
| In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of … A McCahill, T McSorley, E Huston, EV Hill, MJ Lynch, I Gall, G Keryer, ... Cellular signalling 17 (9), 1158-1173, 2005 | 123 | 2005 |
| Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability SN Rampersad, JD Ovens, E Huston, MB Umana, LS Wilson, ... Journal of biological chemistry 285 (44), 33614-33622, 2010 | 108 | 2010 |
| Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and β1 integrin and for tumor cell proliferation and migration PA Kiely, GS Baillie, MJ Lynch, MD Houslay, R O'Connor Journal of Biological Chemistry 283 (34), 22952-22961, 2008 | 92 | 2008 |
| MEK1 binds directly to βarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization D Meng, MJ Lynch, E Huston, M Beyermann, J Eichhorst, DR Adams, ... Journal of Biological Chemistry 284 (17), 11425-11435, 2009 | 78 | 2009 |
| β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation DF Anthony, YY Sin, S Vadrevu, N Advant, JP Day, AM Byrne, MJ Lynch, ... Molecular and cellular biology 31 (5), 1066-1075, 2011 | 73 | 2011 |
| The Aeromonas hydrophila LuxR homologue AhyR regulates the N-acyl homoserine lactone synthase, AhyI positively and negatively in a growth phase … DF Kirke, S Swift, MJ Lynch, P Williams FEMS microbiology letters 241 (1), 109-117, 2004 | 69 | 2004 |
| Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during β2-adrenoceptor and prostanoid receptor cAMP signaling D Willoughby, GS Baillie, MJ Lynch, A Ciruela, MD Houslay, DMF Cooper Journal of biological chemistry 282 (47), 34235-34249, 2007 | 57 | 2007 |
| Intracellular targeting of phosphodiesterase‐4 underpins compartmentalized cAMP signaling MJ Lynch, EV Hill, MD Houslay Current topics in developmental biology 75, 225-259, 2006 | 57 | 2006 |
| The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon‐like peptide‐1 release WK Ong, FM Gribble, F Reimann, MJ Lynch, MD Houslay, GS Baillie, ... British journal of pharmacology 157 (4), 633-644, 2009 | 56 | 2009 |
| cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell … MJ Lynch, GS Baillie, MD Houslay Biochemical Society Transactions 35 (5), 938-941, 2007 | 53 | 2007 |
| Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293β2 cells and cardiac myocytes X Li, E Huston, MJ Lynch, MD Houslay, GS Baillie Biochemical Journal 394 (2), 427-435, 2006 | 51 | 2006 |
| Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene LA Johnston, S Erdogan, YF Cheung, M Sullivan, R Barber, MJ Lynch, ... Biochemical Journal 380 (2), 371-384, 2004 | 32 | 2004 |
| Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice LM Gronning, GS Baillie, A Cederberg, MJ Lynch, MD Houslay, ... FEBS letters 580 (17), 4126-4130, 2006 | 24 | 2006 |
