Patrick A. Lewis
Patrick A. Lewis
Підтверджена електронна адреса в rvc.ac.uk - Домашня сторінка
Назва
Посилання
Посилання
Рік
Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich, ...
Autophagy 12 (1), 1-222, 2016
70402016
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
E Greggio, S Jain, A Kingsbury, R Bandopadhyay, P Lewis, A Kaganovich, ...
Neurobiology of disease 23 (2), 329-341, 2006
7002006
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
MJ Devine, M Ryten, P Vodicka, AJ Thomson, T Burdon, H Houlden, ...
Nature communications 2 (1), 1-10, 2011
3912011
α-Synucleinopathy associated with G51D SNCA mutation: A link between Parkinson’s disease and multiple system atrophy?
AP Kiely, YT Asi, E Kara, P Limousin, H Ling, P Lewis, C Proukakis, ...
Acta neuropathologica 125 (5), 753-769, 2013
3252013
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
E Greggio, I Zambrano, A Kaganovich, A Beilina, JM Taymans, V Daniëls, ...
Journal of Biological Chemistry 283 (24), 16906-16914, 2008
3122008
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
PA Lewis, E Greggio, A Beilina, S Jain, A Baker, MR Cookson
Biochemical and biophysical research communications 357 (3), 668-671, 2007
2982007
The genetics of Parkinson's syndromes: a critical review
J Hardy, P Lewis, T Revesz, A Lees, C Paisan-Ruiz
Current opinion in genetics & development 19 (3), 254-265, 2009
2392009
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
VS Burchell, DE Nelson, A Sanchez-Martinez, M Delgado-Camprubi, ...
Nature neuroscience 16 (9), 1257-1265, 2013
2332013
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
J Deng, PA Lewis, E Greggio, E Sluch, A Beilina, MR Cookson
Proceedings of the National Academy of Sciences 105 (5), 1499-1504, 2008
2322008
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences
C Manzoni, DA Kia, J Vandrovcova, J Hardy, NW Wood, PA Lewis, ...
Briefings in bioinformatics 19 (2), 286-302, 2018
2162018
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
MA Nalls, C Blauwendraat, CL Vallerga, K Heilbron, S Bandres-Ciga, ...
The Lancet Neurology 18 (12), 1091-1102, 2019
2142019
DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA
S Camargos, S Scholz, J Simón-Sánchez, C Paisán-Ruiz, P Lewis, ...
The Lancet Neurology 7 (3), 207-215, 2008
1962008
Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS‐1 mutations that lead to exceptionally high amyloid‐β concentrations
H Houlden, M Baker, E McGowan, P Lewis, M Hutton, R Crook, NW Wood, ...
Annals of neurology 48 (5), 806-808, 2000
1602000
Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase
A Mudher, S Chapman, J Richardson, A Asuni, G Gibb, C Pollard, ...
Journal of Neuroscience 21 (14), 4987-4995, 2001
1512001
Cancer and neurodegeneration: between the devil and the deep blue sea
H Plun-Favreau, PA Lewis, J Hardy, LM Martins, NW Wood
PLoS Genet 6 (12), e1001257, 2010
1352010
Inhibition of LRRK2 kinase activity stimulates macroautophagy
C Manzoni, A Mamais, S Dihanich, R Abeti, MPM Soutar, H Plun-Favreau, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1833 (12), 2900-2910, 2013
1292013
Cell-free assays for γ-secretase activity
C McLendon, TP Xin, C Ziani-Cherif, MP Murphy, KA Findlay, PA Lewis, ...
The FASEB Journal 14 (15), 2383-2386, 2000
1262000
Presenilin 1 Regulates Pharmacologically Distinct γ-Secretase Activities IMPLICATIONS FOR THE ROLE OF PRESENILIN IN γ-SECRETASE CLEAVAGE
MP Murphy, SN Uljon, PE Fraser, A Fauq, HA Lookingbill, KA Findlay, ...
Journal of Biological Chemistry 275 (34), 26277-26284, 2000
1172000
A presenilin 1 mutation associated with familial frontotemporal dementia inhibits γ-secretase cleavage of APP and notch
Z Amtul, PA Lewis, S Piper, R Crook, M Baker, K Findlay, A Singleton, ...
Neurobiology of disease 9 (2), 269-273, 2002
1162002
Genetic neuropathology of Parkinson's disease
MR Cookson, J Hardy, PA Lewis
International journal of clinical and experimental pathology 1 (3), 217, 2008
1132008
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Статті 1–20