Haruki Hasegawa
Haruki Hasegawa
Michigan | NIH | Bayer | Amgen
Підтверджена електронна адреса в amgen.com - Домашня сторінка
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Посилання
Рік
Mammalian ykt6 is a neuronal SNARE targeted to a specialized compartment by its profilin-like amino terminal domain
H Hasegawa, S Zinsser, Y Rhee, EO Vik-Mo, S Davanger, JC Hay
Molecular biology of the cell 14 (2), 698-720, 2003
862003
A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
D Smith, H Helgason, P Sulem, US Bjornsdottir, AC Lim, ...
PLoS Genetics 13 (3), e1006659, 2017
832017
A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism
Z Liu, EC Leng, K Gunasekaran, M Pentony, M Shen, M Howard, J Stoops, ...
Journal of Biological Chemistry 290 (12), 7535-7562, 2015
662015
Native IL-32 is released from intestinal epithelial cells via a non-classical secretory pathway as a membrane-associated protein
H Hasegawa, HJ Thomas, K Schooley, TL Born
Cytokine 53 (1), 74-83, 2011
662011
Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6
H Hasegawa, Z Yang, L Oltedal, S Davanger, JC Hay
Journal of cell science 117 (19), 4495-4508, 2004
662004
In Vivo Crystallization of Human IgG in the Endoplasmic Reticulum of Engineered Chinese Hamster Ovary (CHO) Cells
H Hasegawa, J Wendling, F He, E Trilisky, R Stevenson, H Franey, ...
Journal of Biological Chemistry 286 (22), 19917-19931, 2011
622011
Russell body inducing threshold depends on the variable domain sequences of individual human IgG clones and the cellular protein homeostasis
J Stoops, S Byrd, H Hasegawa
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (10), 1643-1657, 2012
382012
Fusion partners can increase the expression of recombinant interleukins via transient transfection in 2936E cells
J Carter, J Zhang, TL Dang, H Hasegawa, JD Cheng, I Gianan, JW O'Neill, ...
Protein Science 19 (2), 357-362, 2010
322010
Aggregates, Crystals, Gels, and Amyloids: Intracellular and Extracellular Phenotypes at the Crossroads of Immunoglobulin Physicochemical Property and Cell Physiology
H Hasegawa
International Journal of Cell Biology 2013, 2013
232013
Development of a high-throughput fluoroimmunoassay for Syk kinase and Syk kinase inhibitors
N Yamamoto, H Hasegawa, H Seki, K Ziegelbauer, T Yasuda
Analytical biochemistry 315 (2), 256-261, 2003
192003
Russell body phenotype is preferentially induced by IgG mAb clones with high intrinsic condensation propensity: relations between the biosynthetic events in the ER and solution …
H Hasegawa, CE Woods, F Kinderman, F He, AC Lim
mAbs 6 (6), 1518-1532, 2014
162014
R‐SNARE ykt6 resides in membrane‐associated protease‐resistant protein particles and modulates cell cycle progression when over‐expressed
N Thayanidhi, Y Liang, H Hasegawa, DC Nycz, V Oorschot, ...
Biology of the Cell 104 (7), 397-417, 2012
162012
Modulation of in vivo IgG crystallization in the secretory pathway by heavy chain isotype class switching and N-linked glycosylation
H Hasegawa, C Forte, I Barber, S Turnbaugh, J Stoops, M Shen, AC Lim
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1843 (7), 1325–1338, 2014
142014
Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG …
H Hasegawa, A Hsu, CE Tinberg, KE Siegler, AA Nazarian, MM Tsai
mAbs 9 (5), 854-873, 2017
102017
Simultaneous induction of distinct protein phase separation events in multiple subcellular compartments of a single cell
H Hasegawa
Experimental cell research 379 (1), 92-109, 2019
62019
Topogenesis and cell surface trafficking of GPR34 are facilitated by positive-inside rule that effects through a tri-basic motif in the first intracellular loop
H Hasegawa, N Patel, E Ettehadieh, P Li, AC Lim
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1863 (7), 1534-1551, 2016
62016
CYCLIC CARBOXYLIC ACIDS AS INTEGRIN ANTAGONISTS
T Lehmann, R Fischer, M Albers, T Roelle, G Mueller, G Hessler, M Tajimi, ...
EP Patent 1,276,714, 2003
52003
CYCLIC CARBOXYLIC ACIDS AS INTEGRIN ANTAGONISTS
T LEHMANN, T RÖLLE, M ALBERS, G MÜLLER, G HEßLER, R FISCHER, ...
WO Patent 2,002,030,876, 2002
52002
Overexpression of cryoglobulin‐like single‐chain antibody induces morular cell phenotype via liquid–liquid phase separation in the secretory pathway organelles
H Hasegawa, N Patel, AC Lim
FEBS Journal 282 (15), 2777-2795, 2015
42015
Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31
M Shen, S Siu, S Byrd, KH Edelmann, N Patel, RR Ketchem, C Mehlin, ...
Experimental Cell Research 317 (7), 976-993, 2011
32011
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