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Michael P Hay
Michael P Hay
Associate Professor, University of Auckland
Verified email at auckland.ac.nz - Homepage
Title
Cited by
Cited by
Year
Targeting hypoxia in cancer therapy
WR Wilson, MP Hay
Nature Reviews Cancer 11 (6), 393-410, 2011
32272011
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality
DA Chan, PD Sutphin, P Nguyen, S Turcotte, EW Lai, A Banh, ...
Science translational medicine 3 (94), 94ra70-94ra70, 2011
5642011
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy
S Turcotte, DA Chan, PD Sutphin, MP Hay, WA Denny, AJ Giaccia
Cancer cell 14 (1), 90-102, 2008
2792008
Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs
KO Hicks, FB Pruijn, TW Secomb, MP Hay, R Hsu, JM Brown, WA Denny, ...
Journal of the National Cancer Institute 98 (16), 1118-1128, 2006
1742006
Recent developments in the design of bioreductive drugs.
WA Denny, WR Wilson, MP Hay
The British journal of cancer. Supplement 27, S32, 1996
1401996
Structure− activity relationships of 1, 2, 4-benzotriazine 1, 4-dioxides as hypoxia-selective analogues of tirapazamine
MP Hay, SA Gamage, MS Kovacs, FB Pruijn, RF Anderson, AV Patterson, ...
Journal of medicinal chemistry 46 (1), 169-182, 2003
1392003
Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors
KO Hicks, BG Siim, JK Jaiswal, FB Pruijn, AM Fraser, R Patel, A Hogg, ...
Clinical Cancer Research 16 (20), 4946-4957, 2010
1372010
Activation of 3-amino-1, 2, 4-benzotriazine 1, 4-dioxide antitumor agents to oxidizing species following their one-electron reduction
RF Anderson, SS Shinde, MP Hay, SA Gamage, WA Denny
Journal of the American Chemical Society 125 (3), 748-756, 2003
1302003
Targeting growth hormone function: strategies and therapeutic applications
M Lu, JU Flanagan, RJ Langley, MP Hay, JK Perry
Signal transduction and targeted therapy 4 (1), 3, 2019
1212019
DNA-targeted 1, 2, 4-benzotriazine 1, 4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine
MP Hay, FB Pruijn, SA Gamage, HDS Liyanage, MS Kovacs, ...
Journal of medicinal chemistry 47 (2), 475-488, 2004
1012004
Hypoxia-selective antitumor agents. 8. Bis (nitroimidazolyl) alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitizers
MP Hay, WR Wilson, JW Moselen, BD Palmer, WA Denny
Journal of medicinal chemistry 37 (3), 381-391, 1994
1001994
Tricyclic [1, 2, 4] triazine 1, 4-dioxides as hypoxia selective cytotoxins
MP Hay, KO Hicks, K Pchalek, HH Lee, A Blaser, FB Pruijn, RF Anderson, ...
Journal of medicinal chemistry 51 (21), 6853-6865, 2008
932008
Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy
MP Hay, RF Anderson, DM Ferry, WR Wilson, WA Denny
Journal of medicinal chemistry 46 (25), 5533-5545, 2003
932003
Chemical space mimicry for drug discovery
W Yuan, D Jiang, DK Nambiar, LP Liew, MP Hay, J Bloomstein, P Lu, ...
Journal of chemical information and modeling 57 (4), 875-882, 2017
882017
4-Pyridylanilinothiazoles that selectively target von Hippel− Lindau deficient renal cell carcinoma cells by inducing autophagic cell death
MP Hay, S Turcotte, JU Flanagan, M Bonnet, DA Chan, PD Sutphin, ...
Journal of medicinal chemistry 53 (2), 787-797, 2010
832010
A 2-nitroimidazole carbamate prodrug of 5-amino-1-(chloromethyl)-3-[(5, 6, 7-trimethoxyindol-2-yl) carbonyl]-1, 2-dihydro-3H-benz [e] indole (amino-seco-CBI-TMI) for use with …
MP Hay, BM Sykes, WA Denny, WR Wilson
Bioorganic & medicinal chemistry letters 9 (15), 2237-2242, 1999
831999
Selective reaction of glycine residues in hydrogen atom transfer from amino acid derivatives
VA Burgess, CJ Easton, MP Hay
Journal of the American Chemical Society 111 (3), 1047-1052, 1989
791989
The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia
J Wang, A Foehrenbacher, J Su, R Patel, MP Hay, KO Hicks, WR Wilson
Clinical Cancer Research 18 (6), 1684-1695, 2012
732012
Spin Trapping of Radicals Other Than the OH Radical upon Reduction of the Anticancer Agent Tirapazamine by Cytochrome P450 Reductase
SS Shinde, MP Hay, AV Patterson, WA Denny, RF Anderson
Journal of the American Chemical Society 131 (40), 14220-14221, 2009
722009
Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures
FB Pruijn, JR Sturman, HDS Liyanage, KO Hicks, MP Hay, WR Wilson
Journal of medicinal chemistry 48 (4), 1079-1087, 2005
692005
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