| Slow-and tight-binding inhibitors of the 85-kDa human phospholipase A2 IP Street, HK Lin, F Laliberte, F Ghomashchi, Z Wang, H Perrier, ... Biochemistry 32 (23), 5935-5940, 1993 | 503 | 1993 |
| Structure-guided design of a selective BCL-XL inhibitor G Lessene, PE Czabotar, BE Sleebs, K Zobel, KN Lowes, JM Adams, ... Nature chemical biology 9 (6), 390-397, 2013 | 422 | 2013 |
| Unequivocal demonstration of the involvement of a glutamate residue as a nucleophile in the mechanism of a retaining glycosidase SG Withers, RAJ Warren, IP Street, K Rupitz, JB Kempton, R Aebersold Journal of the American Chemical Society 112 (15), 5887-5889, 1990 | 312 | 1990 |
| SOCS2 negatively regulates growth hormone action in vitro and in vivo CJ Greenhalgh, E Rico-Bautista, M Lorentzon, AL Thaus, PO Morgan, ... The Journal of clinical investigation 115 (2), 397-406, 2005 | 297 | 2005 |
| 2-Deoxy-2-fluoro-D-glycosyl fluorides. A new class of specific mechanism-based glycosidase inhibitors. SG Withers, K Rupitz, IP Street Journal of Biological Chemistry 263 (17), 7929-7932, 1988 | 268 | 1988 |
| Hydrogen bonding and specificity. Fluorodeoxy sugars as probes of hydrogen bonding in the glycogen phosphorylase-glucose complex IP Street, CR Armstrong, SG Withers Biochemistry 25 (20), 6021-6027, 1986 | 241 | 1986 |
| 2-Deoxy-2-fluoroglucosides: a novel class of mechanism-based glucosidase inhibitors SG Withers, IP Street, P Bird, DH Dolphin Journal of the American Chemical Society 109 (24), 7530-7531, 1987 | 221 | 1987 |
| Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth JB Baell, DJ Leaver, SJ Hermans, GL Kelly, MS Brennan, NL Downer, ... Nature 560 (7717), 253-257, 2018 | 208 | 2018 |
| Identification of a covalent. alpha.-D-glucopyranosyl enzyme intermediate formed on a. beta.-glucosidase SG Withers, IP Street Journal of the American Chemical Society 110 (25), 8551-8553, 1988 | 194 | 1988 |
| Inactivation of a. beta.-glucosidase through the accumulation of a stable 2-deoxy-2-fluoro-. alpha.-D-glucopyranosyl-enzyme intermediate: a detailed investigation IP Street, JB Kempton, SG Withers Biochemistry 31 (41), 9970-9978, 1992 | 174 | 1992 |
| An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery LF Willoughby, T Schlosser, SA Manning, JP Parisot, IP Street, ... Disease models & mechanisms 6 (2), 521-529, 2013 | 165 | 2013 |
| Isopentenyl diphosphate: dimethylallyl diphosphate isomerase: an improved purification of the enzyme and isolation of the gene from Saccharomyces cerevisiae MS Anderson, M Muehlbacher, IP Street, J Proffitt, CD Poulter Journal of Biological Chemistry 264 (32), 19169-19175, 1989 | 161 | 1989 |
| Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein … S Patterson, MS Alphey, DC Jones, EJ Shanks, IP Street, JA Frearson, ... Journal of medicinal chemistry 54 (19), 6514-6530, 2011 | 141 | 2011 |
| NMR structural studies of the tight complex between a trifluoromethyl ketone inhibitor and the 85-kDa human phospholipase A2 LA Trimble, IP Street, H Perrier, NM Tremblay, PK Weech, MA Bernstein Biochemistry 32 (47), 12560-12565, 1993 | 129 | 1993 |
| HBO1 is required for the maintenance of leukaemia stem cells L MacPherson, J Anokye, MM Yeung, EYN Lam, YC Chan, CF Weng, ... Nature 577 (7789), 266-270, 2020 | 124 | 2020 |
| The synthesis and hydrolysis of a series of deoxyfluoro-D-glucopyranosyl phosphates SG Withers, DJ MacLennan, IP Street Carbohydrate research 154 (1), 127-144, 1986 | 112 | 1986 |
| Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma S AbuHammad, C Cullinane, C Martin, Z Bacolas, T Ward, H Chen, ... Proceedings of the National Academy of Sciences 116 (36), 17990-18000, 2019 | 88 | 2019 |
| Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity GA Holloway, WN Charman, AH Fairlamb, R Brun, M Kaiser, E Kostewicz, ... Antimicrobial Agents and Chemotherapy 53 (7), 2824-2833, 2009 | 87 | 2009 |
| Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-XL BE Sleebs, WJA Kersten, S Kulasegaram, G Nikolakopoulos, E Hatzis, ... Journal of Medicinal Chemistry 56 (13), 5514-5540, 2013 | 83 | 2013 |
| Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity BE Sleebs, PE Czabotar, WJ Fairbrother, WD Fairlie, JA Flygare, ... Journal of medicinal chemistry 54 (6), 1914-1926, 2011 | 83 | 2011 |
