Disease variants alter transcription factor levels and methylation of their binding sites MJ Bonder, R Luijk, DV Zhernakova, M Moed, P Deelen, M Vermaat, ... Nature genetics 49 (1), 131, 2017 | 443 | 2017 |
Genetic and environmental influences interact with age and sex in shaping the human methylome J Van Dongen, MG Nivard, G Willemsen, JJ Hottenga, Q Helmer, ... Nature communications 7, 11115, 2016 | 345 | 2016 |
Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited J Deelen, M Beekman, HW Uh, Q Helmer, M Kuningas, L Christiansen, ... Aging cell 10 (4), 686-698, 2011 | 318 | 2011 |
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age J Deelen, M Beekman, HW Uh, L Broer, KL Ayers, Q Tan, Y Kamatani, ... Human molecular genetics 23 (16), 4420-4432, 2014 | 280 | 2014 |
A genome‐wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22 HJM Kerkhof, RJ Lories, I Meulenbelt, I Jonsdottir, AM Valdes, P Arp, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2010 | 276 | 2010 |
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array RC Slieker, SD Bos, JJ Goeman, JVMG Bovée, RP Talens, ... Epigenetics & chromatin 6 (1), 26, 2013 | 256 | 2013 |
Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis I Meulenbelt, JL Min, S Bos, N Riyazi, JJ Houwing-Duistermaat, ... Human molecular genetics 17 (12), 1867-1875, 2008 | 256 | 2008 |
A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5′ UTR of GDF5 with osteoarthritis susceptibility K Chapman, A Takahashi, I Meulenbelt, C Watson, J Rodriguez-Lopez, ... Human molecular genetics 17 (10), 1497-1504, 2008 | 220 | 2008 |
Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study YFM Ramos, W den Hollander, JVMG Bovée, N Bomer, ... PloS one 9 (7), e103056, 2014 | 185 | 2014 |
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity M Beekman, C Nederstigt, HED Suchiman, D Kremer, R van der Breggen, ... Proceedings of the National Academy of Sciences 107 (42), 18046-18049, 2010 | 176 | 2010 |
Improving phenotypic prediction by combining genetic and epigenetic associations S Shah, MJ Bonder, RE Marioni, Z Zhu, AF McRae, A Zhernakova, ... The American Journal of Human Genetics 97 (1), 75-85, 2015 | 148 | 2015 |
Gene expression analysis of mTOR pathway: association with human longevity WM Passtoors, M Beekman, J Deelen, R van der Breggen, AB Maier, ... Aging Cell 12 (1), 24-31, 2013 | 145 | 2013 |
A 40-marker panel for high dimensional characterization of the cancer immune microenvironment by imaging mass cytometry ME Ijsselsteijn, R van der Breggen, A Farina Sarasqueta, F Koning, ... Frontiers in immunology 10, 2534, 2019 | 123 | 2019 |
Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches W Den Hollander, YFM Ramos, SD Bos, N Bomer, R van der Breggen, ... Annals of the rheumatic diseases 73 (12), 2208-2212, 2014 | 118 | 2014 |
High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity NL de Vries, V Van Unen, ME Ijsselsteijn, T Abdelaal, R Van Der Breggen, ... Gut, gutjnl-2019-318672, 2019 | 114 | 2019 |
Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis N Bomer, W den Hollander, YFM Ramos, SD Bos, R van der Breggen, ... Annals of the rheumatic diseases 74 (8), 1571-1579, 2015 | 97 | 2015 |
Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs I Ricaño-Ponce, DV Zhernakova, P Deelen, O Luo, X Li, A Isaacs, ... Journal of autoimmunity 68, 62-74, 2016 | 79 | 2016 |
Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues SD Bos, JVMG Bovée, BJ Duijnisveld, EVA Raine, WJ van Dalen, ... Annals of the rheumatic diseases 71 (7), 1254-1258, 2012 | 74 | 2012 |
Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations I Meulenbelt, K Chapman, R Dieguez-Gonzalez, D Shi, A Tsezou, J Dai, ... Human molecular genetics 18 (8), 1518-1523, 2009 | 73 | 2009 |
Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility I Meulenbelt, SD Bos, K Chapman, R van der Breggen, ... Annals of the rheumatic diseases 70 (1), 164-167, 2011 | 64 | 2011 |