Diane Hanger
Diane Hanger
Professor of Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience
Підтверджена електронна адреса в kcl.ac.uk - Домашня сторінка
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase
DP Hanger, K Hughes, JR Woodgett, JP Brion, BH Anderton
Neuroscience letters 147 (1), 58-62, 1992
Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
DP Hanger, BH Anderton, W Noble
Trends in molecular medicine 15 (3), 112-119, 2009
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
S Lovestone, CH Reynolds, D Latimer, DR Davis, BH Anderton, JM Gallo, ...
Current Biology 4 (12), 1077-1086, 1994
New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament‐tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry
DP Hanger, JC Betts, TLF Loviny, WP Blackstock, BH Anderton
Journal of neurochemistry 71 (6), 2465-2476, 1998
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
DP Hanger, HL Byers, S Wray, KY Leung, MJ Saxton, A Seereeram, ...
Journal of Biological Chemistry 282 (32), 23645-23654, 2007
Physiological release of endogenous tau is stimulated by neuronal activity
AM Pooler, EC Phillips, DHW Lau, W Noble, DP Hanger
EMBO reports 14 (4), 389-394, 2013
Roles of tau protein in health and disease
T Guo, W Noble, DP Hanger
Acta neuropathologica 133 (5), 665-704, 2017
Astrocytes are important mediators of A β-induced neurotoxicity and tau phosphorylation in primary culture
CJ Garwood, AM Pooler, J Atherton, DP Hanger, W Noble
Cell death & disease 2 (6), e167-e167, 2011
Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cγ1, Grb2, and Src family kinases
CH Reynolds, CJ Garwood, S Wray, C Price, S Kellie, T Perera, ...
Journal of Biological Chemistry 283 (26), 18177-18186, 2008
The importance of tau phosphorylation for neurodegenerative diseases
W Noble, DP Hanger, CCJ Miller, S Lovestone
Frontiers in neurology 4, 83, 2013
Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule‐binding repeat domains as demonstrated by new specific …
R De Silva, T Lashley, G Gibb, D Hanger, A Hope, A Reid, ...
Neuropathology and applied neurobiology 29 (3), 288-302, 2003
Induction of neuronal death by α‐synuclein
AR Saha, NN Ninkina, DP Hanger, BH Anderton, AM Davies, ...
European Journal of Neuroscience 12 (8), 3073-3077, 2000
Parkinson's disease α-synuclein mutations exhibit defective axonal transport in cultured neurons
AR Saha, J Hill, MA Utton, AA Asuni, S Ackerley, AJ Grierson, CC Miller, ...
Journal of cell science 117 (7), 1017-1024, 2004
Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase
P Derkinderen, TME Scales, DP Hanger, KY Leung, HL Byers, MA Ward, ...
Journal of Neuroscience 25 (28), 6584-6593, 2005
Collapsin response mediator protein‐2 hyperphosphorylation is an early event in Alzheimer’s disease progression
AR Cole, W Noble, L Aalten, F Plattner, R Meimaridou, D Hogan, M Taylor, ...
Journal of neurochemistry 103 (3), 1132-1144, 2007
Tau in Alzheimer neurofibrillary tangles. N-and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal …
JP Brion, DP Hanger, MT Bruce, AM Couck, J Flament-Durand, ...
Biochemical journal 273 (1), 127-133, 1991
Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin
I Cuchillo‐Ibanez, A Seereeram, HL Byers, KY Leung, MA Ward, ...
The FASEB Journal 22 (9), 3186-3195, 2008
A role for tau at the synapse in Alzheimer's disease pathogenesis
AM Pooler, W Noble, DP Hanger
Neuropharmacology 76, 1-8, 2014
Molecular motors implicated in the axonal transport of tau and α-synuclein
MA Utton, WJ Noble, JE Hill, BH Anderton, DP Hanger
Journal of cell science 118 (20), 4645-4654, 2005
The ER-mitochondria tethering complex VAPB-PTPIP51 regulates autophagy
P Gomez-Suaga, S Paillusson, R Stoica, W Noble, DP Hanger, CCJ Miller
Current Biology 27 (3), 371-385, 2017
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