Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis N Cabezas-Wallscheid, D Klimmeck, J Hansson, DB Lipka, A Reyes, ... Cell stem cell 15 (4), 507-522, 2014 | 567 | 2014 |
FLT3 as a therapeutic target in AML: still challenging after all these years T Kindler, DB Lipka, T Fischer Blood, The Journal of the American Society of Hematology 116 (24), 5089-5102, 2010 | 472 | 2010 |
DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia CC Oakes, M Seifert, Y Assenov, L Gu, M Przekopowitz, AS Ruppert, ... Nature genetics 48 (3), 253-264, 2016 | 322 | 2016 |
Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain F Heidel, FK Solem, F Breitenbuecher, DB Lipka, S Kasper, MH Thiede, ... Blood 107 (1), 293-300, 2006 | 322 | 2006 |
DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats D Brocks, CR Schmidt, M Daskalakis, HS Jang, NM Shah, D Li, J Li, ... Nature genetics 49 (7), 1052-1060, 2017 | 270 | 2017 |
Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer D Brocks, Y Assenov, S Minner, O Bogatyrova, R Simon, C Koop, ... Cell reports 8 (3), 798-806, 2014 | 270 | 2014 |
Disclosure of candidate genes in acute myeloid leukemia with complex karyotypes using microarray-based molecular characterization FG Rücker, L Bullinger, C Schwaenen, DB Lipka, S Wessendorf, ... J Clin Oncol 24 (24), 3887-3894, 2006 | 195 | 2006 |
Skin cancer classification via convolutional neural networks: systematic review of studies involving human experts S Haggenmüller, RC Maron, A Hekler, JS Utikal, C Barata, RL Barnhill, ... European Journal of Cancer 156, 202-216, 2021 | 169 | 2021 |
Comprehensive genomic and transcriptomic analysis for guiding therapeutic decisions in patients with rare cancers P Horak, C Heining, S Kreutzfeldt, B Hutter, A Mock, J Hüllein, M Fröhlich, ... Cancer discovery 11 (11), 2780-2795, 2021 | 156 | 2021 |
Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals S Schwoerer, F Becker, C Feller, AH Baig, U Koeber, H Henze, JM Kraus, ... Nature 540 (7633), 428-432, 2016 | 124 | 2016 |
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia DB Lipka, T Witte, R Toth, J Yang, M Wiesenfarth, P Nöllke, A Fischer, ... Nature communications 8 (1), 2126, 2017 | 114 | 2017 |
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging R Bogeska, AM Mikecin, P Kaschutnig, M Fawaz, M Büchler-Schäff, D Le, ... Cell stem cell 29 (8), 1273-1284. e8, 2022 | 98 | 2022 |
Addition of rituximab to standard therapy improves response rate and progression-free survival in relapsed or refractory thrombotic thrombocytopenic purpura and autoimmune … F Heidel, DB Lipka, C von Auer, C Huber, I Scharrer, G Hess Thrombosis and haemostasis 97 (02), 228-233, 2007 | 84 | 2007 |
Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia E Stieglitz, T Mazor, AB Olshen, H Geng, LC Gelston, J Akutagawa, ... Nature communications 8 (1), 2127, 2017 | 83 | 2017 |
Combining CNN-based histologic whole slide image analysis and patient data to improve skin cancer classification J Höhn, E Krieghoff-Henning, TB Jutzi, C von Kalle, JS Utikal, F Meier, ... European Journal of Cancer 149, 94-101, 2021 | 80 | 2021 |
Rare occurrence of the JAK2 V617F mutation in AML subtypes M5, M6, and M7 S Fröhling, DB Lipka, S Kayser, C Scholl, RF Schlenk, H Döhner, ... Blood 107 (3), 1242-1243, 2006 | 79 | 2006 |
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells A Grigoryan, N Guidi, K Senger, T Liehr, K Soller, G Marka, A Vollmer, ... Genome biology 19, 1-21, 2018 | 76 | 2018 |
Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-γ1-driven activation of mTOR/p70S6-kinase pathway B Markova, C Albers, F Breitenbuecher, JV Melo, TH Brümmendorf, ... Oncogene 29 (5), 739-751, 2010 | 75 | 2010 |
Integrative analysis defines distinct prognostic subgroups of intrahepatic cholangiocarcinoma B Goeppert, R Toth, S Singer, T Albrecht, DB Lipka, P Lutsik, D Brocks, ... Hepatology 69 (5), 2091-2106, 2019 | 72 | 2019 |
Explainable artificial intelligence in skin cancer recognition: A systematic review K Hauser, A Kurz, S Haggenmüller, RC Maron, C von Kalle, JS Utikal, ... European Journal of Cancer 167, 54-69, 2022 | 61 | 2022 |