Robert Lane
Robert Lane
Associate Professor in Molecular Pharmacology, University of Nottingham
Підтверджена електронна адреса в
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
VP Jaakola, MT Griffith, MA Hanson, V Cherezov, EYT Chien, JR Lane, ...
Science 322 (5905), 1211-1217, 2008
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
RO Dror, HF Green, C Valant, DW Borhani, JR Valcourt, AC Pan, ...
Nature 503 (7475), 295, 2013
Structure-Based Discovery of Novel Chemotypes for Adenosine A2A Receptor Antagonists
V Katritch, VP Jaakola, JR Lane, J Lin, AP IJzerman, M Yeager, I Kufareva, ...
Journal of medicinal chemistry 53 (4), 1799-1809, 2010
The role of kinetic context in apparent biased agonism at GPCRs
CK Herenbrink, DA Sykes, P Donthamsetti, M Canals, T Coudrat, ...
Nature communications 7, 10842, 2016
The best of both worlds? Bitopic orthosteric/allosteric ligands of G protein–coupled receptors
C Valant, J Robert Lane, PM Sexton, A Christopoulos
Annual review of pharmacology and toxicology 52, 153-178, 2012
Bridging the gap: bitopic ligands of G-protein-coupled receptors
JR Lane, PM Sexton, A Christopoulos
Trends in pharmacological sciences 34 (1), 59-66, 2013
A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation
M Canals, JR Lane, A Wen, PJ Scammells, PM Sexton, A Christopoulos
Journal of Biological Chemistry 287 (1), 650-659, 2012
Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D 2 receptors
DA Sykes, H Moore, L Stott, N Holliday, JA Javitch, JR Lane, SJ Charlton
Nature communications 8 (1), 763, 2017
Biased agonism at G protein‐coupled receptors: The promise and the challenges—A medicinal chemistry perspective
J Shonberg, L Lopez, PJ Scammells, A Christopoulos, B Capuano, ...
Medicinal research reviews 34 (6), 1286-1330, 2014
A new mechanism of allostery in a G protein–coupled receptor dimer
JR Lane, P Donthamsetti, J Shonberg, CJ Draper-Joyce, S Dentry, ...
Nature chemical biology 10 (9), 745-752, 2014
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
A Gillis, AB Gondin, A Kliewer, J Sanchez, HD Lim, C Alamein, ...
Science Signaling 13 (625), 2020
Ligand Binding and Subtype Selectivity of the Human A2A Adenosine Receptor IDENTIFICATION AND CHARACTERIZATION OF ESSENTIAL AMINO ACID RESIDUES
VP Jaakola, JR Lane, JY Lin, V Katritch, AP IJzerman, RC Stevens
Journal of Biological Chemistry 285 (17), 13032-13044, 2010
A kinetic view of GPCR allostery and biased agonism
JR Lane, LT May, RG Parton, PM Sexton, A Christopoulos
Nature chemical biology 13 (9), 929, 2017
Hybrid Ortho/Allosteric Ligands for the Adenosine A1 Receptor
R Narlawar, JR Lane, M Doddareddy, J Lin, J Brussee, AP IJzerman
Journal of medicinal chemistry 53 (8), 3028-3037, 2010
A structure–activity analysis of biased agonism at the dopamine D2 receptor
J Shonberg, CK Herenbrink, L López, A Christopoulos, PJ Scammells, ...
Journal of medicinal chemistry 56 (22), 9199-9221, 2013
Biased agonism of endogenous opioid peptides at the mu-opioid receptor
GL Thompson, JR Lane, T Coudrat, PM Sexton, A Christopoulos, ...
Molecular pharmacology, mol. 115.098848, 2015
Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors
R Lane, P Chubukov, W Liu, M Canals, V Cherezov, R Abagyan, ...
Molecular pharmacology, mol. 113.088054, 2013
Structure–Activity Relationships of Privileged Structures Lead to the Discovery of Novel Biased Ligands at the Dopamine D2 Receptor
M Szabo, C Klein Herenbrink, A Christopoulos, JR Lane, B Capuano
Journal of medicinal chemistry 57 (11), 4924-4939, 2014
Protean agonism at the dopamine D2 receptor: S-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an antagonist/inverse agonist for Gi1, Gi2 and Gi3
JR Lane, B Powney, A Wise, S Rees, G Milligan
Molecular pharmacology, 2007
Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor
A Abdul-Ridha, L L&oacutepez, P Keov, DM Thal, SN Mistry, PM Sexton, ...
Journal of Biological Chemistry, jbc. M113. 539080, 2014
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