Robert Lane
Robert Lane
Associate Professor in Molecular Pharmacology, University of Nottingham
Підтверджена електронна адреса в nottingham.ac.uk
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The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
VP Jaakola, MT Griffith, MA Hanson, V Cherezov, EYT Chien, JR Lane, ...
Science 322 (5905), 1211-1217, 2008
20582008
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
RO Dror, HF Green, C Valant, DW Borhani, JR Valcourt, AC Pan, ...
Nature 503 (7475), 295, 2013
3582013
Structure-Based Discovery of Novel Chemotypes for Adenosine A2A Receptor Antagonists
V Katritch, VP Jaakola, JR Lane, J Lin, AP IJzerman, M Yeager, I Kufareva, ...
Journal of medicinal chemistry 53 (4), 1799-1809, 2010
2532010
The role of kinetic context in apparent biased agonism at GPCRs
CK Herenbrink, DA Sykes, P Donthamsetti, M Canals, T Coudrat, ...
Nature communications 7, 10842, 2016
2472016
The best of both worlds? Bitopic orthosteric/allosteric ligands of G protein–coupled receptors
C Valant, J Robert Lane, PM Sexton, A Christopoulos
Annual review of pharmacology and toxicology 52, 153-178, 2012
1522012
Bridging the gap: bitopic ligands of G-protein-coupled receptors
JR Lane, PM Sexton, A Christopoulos
Trends in pharmacological sciences 34 (1), 59-66, 2013
1472013
A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation
M Canals, JR Lane, A Wen, PJ Scammells, PM Sexton, A Christopoulos
Journal of Biological Chemistry 287 (1), 650-659, 2012
1142012
Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D 2 receptors
DA Sykes, H Moore, L Stott, N Holliday, JA Javitch, JR Lane, SJ Charlton
Nature communications 8 (1), 763, 2017
1122017
Biased agonism at G protein‐coupled receptors: The promise and the challenges—A medicinal chemistry perspective
J Shonberg, L Lopez, PJ Scammells, A Christopoulos, B Capuano, ...
Medicinal research reviews 34 (6), 1286-1330, 2014
1032014
A new mechanism of allostery in a G protein–coupled receptor dimer
JR Lane, P Donthamsetti, J Shonberg, CJ Draper-Joyce, S Dentry, ...
Nature chemical biology 10 (9), 745-752, 2014
1032014
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
A Gillis, AB Gondin, A Kliewer, J Sanchez, HD Lim, C Alamein, ...
Science Signaling 13 (625), 2020
1012020
Ligand Binding and Subtype Selectivity of the Human A2A Adenosine Receptor IDENTIFICATION AND CHARACTERIZATION OF ESSENTIAL AMINO ACID RESIDUES
VP Jaakola, JR Lane, JY Lin, V Katritch, AP IJzerman, RC Stevens
Journal of Biological Chemistry 285 (17), 13032-13044, 2010
1002010
A kinetic view of GPCR allostery and biased agonism
JR Lane, LT May, RG Parton, PM Sexton, A Christopoulos
Nature chemical biology 13 (9), 929, 2017
982017
Hybrid Ortho/Allosteric Ligands for the Adenosine A1 Receptor
R Narlawar, JR Lane, M Doddareddy, J Lin, J Brussee, AP IJzerman
Journal of medicinal chemistry 53 (8), 3028-3037, 2010
902010
A structure–activity analysis of biased agonism at the dopamine D2 receptor
J Shonberg, CK Herenbrink, L López, A Christopoulos, PJ Scammells, ...
Journal of medicinal chemistry 56 (22), 9199-9221, 2013
892013
Biased agonism of endogenous opioid peptides at the mu-opioid receptor
GL Thompson, JR Lane, T Coudrat, PM Sexton, A Christopoulos, ...
Molecular pharmacology, mol. 115.098848, 2015
882015
Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors
R Lane, P Chubukov, W Liu, M Canals, V Cherezov, R Abagyan, ...
Molecular pharmacology, mol. 113.088054, 2013
812013
Structure–Activity Relationships of Privileged Structures Lead to the Discovery of Novel Biased Ligands at the Dopamine D2 Receptor
M Szabo, C Klein Herenbrink, A Christopoulos, JR Lane, B Capuano
Journal of medicinal chemistry 57 (11), 4924-4939, 2014
722014
Protean agonism at the dopamine D2 receptor: S-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an antagonist/inverse agonist for Gi1, Gi2 and Gi3
JR Lane, B Powney, A Wise, S Rees, G Milligan
Molecular pharmacology, 2007
692007
Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor
A Abdul-Ridha, L L&oacutepez, P Keov, DM Thal, SN Mistry, PM Sexton, ...
Journal of Biological Chemistry, jbc. M113. 539080, 2014
582014
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