| The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist VP Jaakola, MT Griffith, MA Hanson, V Cherezov, EYT Chien, JR Lane, ... Science 322 (5905), 1211-1217, 2008 | 2212 | 2008 |
| Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs RO Dror, HF Green, C Valant, DW Borhani, JR Valcourt, AC Pan, ... Nature 503 (7475), 295, 2013 | 428 | 2013 |
| The role of kinetic context in apparent biased agonism at GPCRs CK Herenbrink, DA Sykes, P Donthamsetti, M Canals, T Coudrat, ... Nature communications 7, 10842, 2016 | 318 | 2016 |
| Structure-Based Discovery of Novel Chemotypes for Adenosine A2A Receptor Antagonists V Katritch, VP Jaakola, JR Lane, J Lin, AP IJzerman, M Yeager, I Kufareva, ... Journal of medicinal chemistry 53 (4), 1799-1809, 2010 | 288 | 2010 |
| Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists A Gillis, AB Gondin, A Kliewer, J Sanchez, HD Lim, C Alamein, ... Science Signaling 13 (625), 2020 | 244 | 2020 |
| Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D 2 receptors DA Sykes, H Moore, L Stott, N Holliday, JA Javitch, JR Lane, SJ Charlton Nature communications 8 (1), 763, 2017 | 192 | 2017 |
| Bridging the gap: bitopic ligands of G-protein-coupled receptors JR Lane, PM Sexton, A Christopoulos Trends in pharmacological sciences 34 (1), 59-66, 2013 | 189 | 2013 |
| The best of both worlds? Bitopic orthosteric/allosteric ligands of G protein–coupled receptors C Valant, J Robert Lane, PM Sexton, A Christopoulos Annual review of pharmacology and toxicology 52, 153-178, 2012 | 186 | 2012 |
| A kinetic view of GPCR allostery and biased agonism JR Lane, LT May, RG Parton, PM Sexton, A Christopoulos Nature chemical biology 13 (9), 929, 2017 | 148 | 2017 |
| A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation M Canals, JR Lane, A Wen, PJ Scammells, PM Sexton, A Christopoulos Journal of Biological Chemistry 287 (1), 650-659, 2012 | 129 | 2012 |
| A new mechanism of allostery in a G protein–coupled receptor dimer JR Lane, P Donthamsetti, J Shonberg, CJ Draper-Joyce, S Dentry, ... Nature chemical biology 10 (9), 745-752, 2014 | 125 | 2014 |
| Biased agonism at G protein‐coupled receptors: The promise and the challenges—A medicinal chemistry perspective J Shonberg, L Lopez, PJ Scammells, A Christopoulos, B Capuano, ... Medicinal research reviews 34 (6), 1286-1330, 2014 | 119 | 2014 |
| Ligand Binding and Subtype Selectivity of the Human A2A Adenosine Receptor IDENTIFICATION AND CHARACTERIZATION OF ESSENTIAL AMINO ACID RESIDUES VP Jaakola, JR Lane, JY Lin, V Katritch, AP IJzerman, RC Stevens Journal of Biological Chemistry 285 (17), 13032-13044, 2010 | 109 | 2010 |
| Hybrid Ortho/Allosteric Ligands for the Adenosine A1 Receptor R Narlawar, JR Lane, M Doddareddy, J Lin, J Brussee, AP IJzerman Journal of medicinal chemistry 53 (8), 3028-3037, 2010 | 109 | 2010 |
| Biased agonism of endogenous opioid peptides at the mu-opioid receptor GL Thompson, JR Lane, T Coudrat, PM Sexton, A Christopoulos, ... Molecular pharmacology, mol. 115.098848, 2015 | 105 | 2015 |
| A structure–activity analysis of biased agonism at the dopamine D2 receptor J Shonberg, CK Herenbrink, L López, A Christopoulos, PJ Scammells, ... Journal of medicinal chemistry 56 (22), 9199-9221, 2013 | 102 | 2013 |
| Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors R Lane, P Chubukov, W Liu, M Canals, V Cherezov, R Abagyan, ... Molecular pharmacology, mol. 113.088054, 2013 | 98 | 2013 |
| β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer A Chang, CP Le, AK Walker, SJ Creed, CK Pon, S Albold, D Carroll, ... Brain, behavior, and immunity 57, 106-115, 2016 | 97 | 2016 |
| β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion SJ Creed, CP Le, M Hassan, CK Pon, S Albold, KT Chan, ME Berginski, ... Breast cancer research 17 (1), 145, 2015 | 86 | 2015 |
| Structure–Activity Relationships of Privileged Structures Lead to the Discovery of Novel Biased Ligands at the Dopamine D2 Receptor M Szabo, C Klein Herenbrink, A Christopoulos, JR Lane, B Capuano Journal of medicinal chemistry 57 (11), 4924-4939, 2014 | 86 | 2014 |
