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Sylvie Guichard
Sylvie Guichard
Director Translational Science Forma Therapeutics
Подтвержден адрес электронной почты в домене astrazeneca.com
Название
Процитировано
Процитировано
Год
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
13127*2021
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
CM Chresta, BR Davies, I Hickson, T Harding, S Cosulich, SE Critchlow, ...
Cancer research 70 (1), 288-298, 2010
9142010
mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling
VS Rodrik-Outmezguine, S Chandarlapaty, NC Pagano, PI Poulikakos, ...
Cancer discovery 1 (3), 248-259, 2011
5152011
Controlling ligand substitution reactions of organometallic complexes: Tuning cancer cell cytotoxicity
F Wang, A Habtemariam, EPL van der Geer, R Fernández, M Melchart, ...
Proceedings of the National Academy of Sciences 102 (51), 18269-18274, 2005
3352005
Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells
P Casado, JC Rodriguez-Prados, SC Cosulich, S Guichard, ...
Science signaling 6 (268), rs6-rs6, 2013
3292013
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein …
KM Foote, K Blades, A Cronin, S Fillery, SS Guichard, L Hassall, I Hickson, ...
Journal of medicinal chemistry 56 (5), 2125-2138, 2013
2442013
Discovery and characterization of AZD6738, a potent inhibitor of ataxia telangiectasia mutated and Rad3 related (ATR) kinase with application as an anticancer agent
KM Foote, JWM Nissink, T McGuire, P Turner, S Guichard, JWT Yates, ...
Journal of medicinal chemistry 61 (22), 9889-9907, 2018
2312018
Cellular determinants of oxaliplatin sensitivity in colon cancer cell lines
S Arnould, I Hennebelle, P Canal, R Bugat, S Guichard
European journal of cancer 39 (1), 112-119, 2003
2242003
The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia
L Willems, N Chapuis, A Puissant, TT Maciel, AS Green, N Jacque, ...
Leukemia 26 (6), 1195-1202, 2012
1822012
Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors
EM Sommer, H Dry, D Cross, S Guichard, BR Davies, DR Alessi
Biochemical Journal 452 (3), 499-508, 2013
1812013
CPT-11 converting carboxylesterase and topoisomerase I activities in tumour and normal colon and liver tissues
S Guichard, C Terret, I Hennebelle, I Lochon, P Chevreau, E Fretigny, ...
British journal of cancer 80 (3), 364-370, 1999
1741999
Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer
LA Stark, K Reid, OJ Sansom, FV Din, S Guichard, I Mayer, DI Jodrell, ...
Carcinogenesis 28 (5), 968-976, 2007
1642007
AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules
SM Guichard, J Curwen, T Bihani, CM D'Cruz, JWT Yates, M Grondine, ...
Molecular cancer therapeutics 14 (11), 2508-2518, 2015
1302015
Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line
S Guichard, I Hennebelle, R Bugat, P Canal
Biochemical pharmacology 55 (5), 667-676, 1998
1271998
Practical treatment guide for dose individualisation in cancer chemotherapy
P Canal, E Chatelut, S Guichard
Drugs 56 (6), 1019-1038, 1998
1211998
Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents
D Antonow, M Kaliszczak, GD Kang, M Coffils, AC Tiberghien, N Cooper, ...
Journal of medicinal chemistry 53 (7), 2927-2941, 2010
1182010
Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells
P Sini, D James, C Chresta, S Guichard
Autophagy 6 (4), 553-554, 2010
1122010
Sequence‐dependent activity of the irinotecan‐5FU combination in human colon‐cancer model HT‐29 in vitro and in vivo
S Guichard, D Cussac, I Hennebelle, R Bugat, P Canal
International journal of cancer 73 (5), 729-734, 1997
1051997
Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055)
SV Holt, A Logie, BR Davies, D Alferez, S Runswick, S Fenton, ...
Cancer research 72 (7), 1804-1813, 2012
1002012
Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium (II …
RL Hayward, QC Schornagel, R Tente, JS Macpherson, RE Aird, ...
Cancer chemotherapy and pharmacology 55, 577-583, 2005
1002005
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Статьи 1–20