Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity JJ Shie, JM Fang, SY Wang, KC Tsai, YSE Cheng, AS Yang, SC Hsiao, ... Journal of the American Chemical Society 129 (39), 11892-11893, 2007 | 246 | 2007 |
Direct conversion of aldehydes to amides, tetrazoles, and triazines in aqueous media by one-pot tandem reactions JJ Shie, JM Fang The Journal of Organic Chemistry 68 (3), 1158-1160, 2003 | 189 | 2003 |
Microwave-assisted one-pot tandem reactions for direct conversion of primary alcohols and aldehydes to triazines and tetrazoles in aqueous media JJ Shie, JM Fang The Journal of organic chemistry 72 (8), 3141-3144, 2007 | 169 | 2007 |
A concise and flexible synthesis of the potent anti-influenza agents tamiflu and tamiphosphor JJ Shie, JM Fang, CH Wong Angewandte Chemie International Edition 47 (31), 5788-5791, 2008 | 165 | 2008 |
Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease CY Wu, KY King, CJ Kuo, JM Fang, YT Wu, MY Ho, CL Liao, JJ Shie, ... Chemistry & biology 13 (3), 261-268, 2006 | 157 | 2006 |
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection JT Jan, TJR Cheng, YP Juang, HH Ma, YT Wu, WB Yang, CW Cheng, ... Proceedings of the National Academy of Sciences 118 (5), e2021579118, 2021 | 151 | 2021 |
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α, β-unsaturated esters JJ Shie, JM Fang, TH Kuo, CJ Kuo, PH Liang, HJ Huang, YT Wu, JT Jan, ... Bioorganic & medicinal chemistry 13 (17), 5240-5252, 2005 | 130 | 2005 |
An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation JJ Shie, YC Liu, YM Lee, C Lim, JM Fang, CH Wong Journal of the American Chemical Society 136 (28), 9953-9961, 2014 | 126 | 2014 |
Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents CJ Kuo, JJ Shie, JM Fang, GR Yen, JTA Hsu, HG Liu, SN Tseng, ... Bioorganic & medicinal chemistry 16 (15), 7388-7398, 2008 | 111 | 2008 |
Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease JJ Shie, JM Fang, CJ Kuo, TH Kuo, PH Liang, HJ Huang, WB Yang, ... Journal of medicinal chemistry 48 (13), 4469-4473, 2005 | 107 | 2005 |
Development of effective anti-influenza drugs: congeners and conjugates–a review JJ Shie, JM Fang Journal of Biomedical Science 26 (1), 84, 2019 | 99 | 2019 |
Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors V Kumar, JS Shin, JJ Shie, KB Ku, C Kim, YY Go, KF Huang, M Kim, ... Antiviral research 141, 101-106, 2017 | 98 | 2017 |
A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity JJ Shie, JM Fang, PT Lai, WH Wen, SY Wang, YSE Cheng, KC Tsai, ... Journal of the American Chemical Society 133 (44), 17959-17965, 2011 | 96 | 2011 |
O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2 PW Lo, JJ Shie, CH Chen, CY Wu, TL Hsu, CH Wong Proceedings of the National Academy of Sciences 115 (28), 7302-7307, 2018 | 77 | 2018 |
Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity YS Chen, HM Yu, JJ Shie, TJR Cheng, CY Wu, JM Fang, CH Wong Bioorganic & medicinal chemistry 22 (5), 1766-1772, 2014 | 70 | 2014 |
Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities JJ Shie, CA Chen, CC Lin, AF Ku, TJR Cheng, JM Fang, CH Wong Organic & biomolecular chemistry 8 (19), 4451-4462, 2010 | 68 | 2010 |
Structural basis of mercury-and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors CC Lee, CJ Kuo, MF Hsu, PH Liang, JM Fang, JJ Shie, AHJ Wang FEBS letters 581 (28), 5454-5458, 2007 | 66 | 2007 |
Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation TT Wei, M Chandy, M Nishiga, A Zhang, KK Kumar, D Thomas, A Manhas, ... Cell 185 (10), 1676-1693. e23, 2022 | 60 | 2022 |
Development of oseltamivir phosphonate congeners as anti-influenza agents TJR Cheng, S Weinheimer, EB Tarbet, JT Jan, YSE Cheng, JJ Shie, ... Journal of medicinal chemistry 55 (20), 8657-8670, 2012 | 58 | 2012 |
A novel, highly efficient and selective desilylating method for trialkylsilyl ethers ASY Lee, HC Yeh, JJ Shie Tetrahedron letters 39 (29), 5249-5252, 1998 | 51 | 1998 |