| Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq I Tirosh, B Izar, SM Prakadan, MH Wadsworth, D Treacy, JJ Trombetta, ... Science 352 (6282), 189-196, 2016 | 3813 | 2016 |
| Genomic correlates of immune-cell infiltrates in colorectal carcinoma M Giannakis, XJ Mu, SA Shukla, ZR Qian, O Cohen, R Nishihara, S Bahl, ... Cell reports 15 (4), 857-865, 2016 | 929 | 2016 |
| Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors VA Adalsteinsson, G Ha, SS Freeman, AD Choudhury, DG Stover, ... Nature communications 8 (1), 1324, 2017 | 738 | 2017 |
| BREX is a novel phage resistance system widespread in microbial genomes T Goldfarb, H Sberro, E Weinstock, O Cohen, S Doron, ... The EMBO journal 34 (2), 169-183, 2015 | 479 | 2015 |
| A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors M Slyper, CBM Porter, O Ashenberg, J Waldman, E Drokhlyansky, ... Nature medicine 26 (5), 792-802, 2020 | 430 | 2020 |
| FastML: a web server for probabilistic reconstruction of ancestral sequences H Ashkenazy, O Penn, A Doron-Faigenboim, O Cohen, G Cannarozzi, ... Nucleic acids research 40 (W1), W580-W584, 2012 | 341 | 2012 |
| Spatially organized multicellular immune hubs in human colorectal cancer K Pelka, M Hofree, JH Chen, S Sarkizova, JD Pirl, V Jorgji, A Bejnood, ... Cell 184 (18), 4734-4752. e20, 2021 | 295 | 2021 |
| Prevalence and mutational determinants of high tumor mutation burden in breast cancer R Barroso-Sousa, E Jain, O Cohen, D Kim, J Buendia-Buendia, E Winer, ... Annals of Oncology 31 (3), 387-394, 2020 | 282 | 2020 |
| Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires D Burstein, F Amaro, T Zusman, Z Lifshitz, O Cohen, JA Gilbert, T Pupko, ... Nature genetics 48 (2), 167-175, 2016 | 273 | 2016 |
| Allele-specific chromatin recruitment and therapeutic vulnerabilities of ESR1 activating mutations R Jeselsohn, JS Bergholz, M Pun, MI Cornwell, W Liu, A Nardone, T Xiao, ... Cancer cell 33 (2), 173-186. e5, 2018 | 233 | 2018 |
| Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor–directed therapies U Nayar, O Cohen, C Kapstad, MS Cuoco, AG Waks, SA Wander, ... Nature genetics 51 (2), 207-216, 2019 | 222 | 2019 |
| The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors in patients with hormone receptor–positive metastatic breast cancer SA Wander, O Cohen, X Gong, GN Johnson, JE Buendia-Buendia, ... Cancer discovery 10 (8), 1174-1193, 2020 | 212 | 2020 |
| The complexity hypothesis revisited: connectivity rather than function constitutes a barrier to horizontal gene transfer O Cohen, U Gophna, T Pupko Molecular biology and evolution 28 (4), 1481-1489, 2011 | 207 | 2011 |
| KDM5 histone demethylase activity links cellular transcriptomic heterogeneity to therapeutic resistance K Hinohara, HJ Wu, S Vigneau, TO McDonald, KJ Igarashi, KN Yamamoto, ... Cancer cell 34 (6), 939-953. e9, 2018 | 184 | 2018 |
| Phenotypic characterization of a comprehensive set of MAPK1/ERK2 missense mutants L Brenan, A Andreev, O Cohen, S Pantel, A Kamburov, D Cacchiarelli, ... Cell reports 17 (4), 1171-1183, 2016 | 149 | 2016 |
| Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments M Janiszewska, DP Tabassum, Z Castaño, S Cristea, KN Yamamoto, ... Nature cell biology 21 (7), 879-888, 2019 | 131 | 2019 |
| Sensitive detection of minimal residual disease in patients treated for early-stage breast cancer HA Parsons, J Rhoades, SC Reed, G Gydush, P Ram, P Exman, K Xiong, ... Clinical Cancer Research 26 (11), 2556-2564, 2020 | 129 | 2020 |
| Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer AG Waks, O Cohen, B Kochupurakkal, D Kim, CE Dunn, JB Buendia, ... Annals of Oncology 31 (5), 590-598, 2020 | 123 | 2020 |
| FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer X Fu, R Pereira, C De Angelis, J Veeraraghavan, S Nanda, L Qin, ... Proceedings of the National Academy of Sciences 116 (52), 26823-26834, 2019 | 120 | 2019 |
| GLOOME: gain loss mapping engine O Cohen, H Ashkenazy, F Belinky, D Huchon, T Pupko Bioinformatics 26 (22), 2914-2915, 2010 | 120 | 2010 |
