| Glycosidase mechanisms: anatomy of a finely tuned catalyst DL Zechel, SG Withers Accounts of chemical research 33 (1), 11-18, 2000 | 1155 | 2000 |
| Phosphonate biochemistry GP Horsman, DL Zechel Chemical reviews 117 (8), 5704-5783, 2017 | 441 | 2017 |
| Mapping the conformational itinerary of β-glycosidases by X-ray crystallography GJ Davies, VMA Ducros, A Varrot, DL Zechel Biochemical Society Transactions 31 (3), 523-527, 2003 | 220 | 2003 |
| Utilization of glyphosate as phosphate source: biochemistry and genetics of bacterial carbon-phosphorus lyase B Hove-Jensen, DL Zechel, B Jochimsen Microbiology and Molecular Biology Reviews 78 (1), 176-197, 2014 | 217 | 2014 |
| Iminosugar glycosidase inhibitors: structural and thermodynamic dissection of the binding of isofagomine and 1-deoxynojirimycin to β-glucosidases DL Zechel, AB Boraston, T Gloster, CM Boraston, JM Macdonald, ... Journal of the American Chemical Society 125 (47), 14313-14323, 2003 | 205 | 2003 |
| Dissection of nucleophilic and acid–base catalysis in glycosidases DL Zechel, SG Withers Current opinion in chemical biology 5 (6), 643-649, 2001 | 195 | 2001 |
| The E358S mutant of Agrobacterium sp. β‐glucosidase is a greatly improved glycosynthase C Mayer, DL Zechel, SP Reid, RAJ Warren, SG Withers FEBS letters 466 (1), 40-44, 2000 | 186 | 2000 |
| Substrate distortion by β-mannanase: Snapshots of the Michaelis and covalent-intermediate complexes suggest a B2, 5 conformation for the transition state VMA Ducros, DL Zechel, GN Murshudov, HJ Gilbert, L Szabó, D Stoll, ... Angewandte Chemie: International Edition, 2002 | 161 | 2002 |
| Glycosidase inhibition: an assessment of the binding of 18 putative transition-state mimics TM Gloster, P Meloncelli, RV Stick, D Zechel, A Vasella, GJ Davies Journal of the American Chemical Society 129 (8), 2345-2354, 2007 | 160 | 2007 |
| β‐Mannosynthase: Synthesis of β‐Mannosides with a Mutant β‐Mannosidase O Nashiru, DL Zechel, D Stoll, T Mohammadzadeh, RAJ Warren, ... Angewandte Chemie 113 (2), 431-434, 2001 | 152 | 2001 |
| Pre-steady state kinetic analysis of an enzymatic reaction monitored by time-resolved electrospray ionization mass spectrometry DL Zechel, L Konermann, SG Withers, DJ Douglas Biochemistry 37 (21), 7664-7669, 1998 | 138 | 1998 |
| Chloramphenicol biosynthesis: the structure of CmlS, a flavin-dependent halogenase showing a covalent flavin–aspartate bond K Podzelinska, R Latimer, A Bhattacharya, LC Vining, DL Zechel, Z Jia Journal of molecular biology 397 (1), 316-331, 2010 | 135 | 2010 |
| An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products CW Johnston, MA Skinnider, MA Wyatt, X Li, MRM Ranieri, L Yang, ... Nature communications 6 (1), 8421, 2015 | 131 | 2015 |
| Understanding how diverse β-mannanases recognize heterogeneous substrates LE Tailford, VMA Ducros, JE Flint, SM Roberts, C Morland, DL Zechel, ... Biochemistry 48 (29), 7009-7018, 2009 | 121 | 2009 |
| Thermal and transition-metal-catalyzed ring-opening polymerization (ROP) of [1] silaferrocenophanes with chlorine substituents at silicon: A route to tunable poly … DL Zechel, KC Hultzsch, R Rulkens, D Balaishis, Y Ni, JK Pudelski, ... Organometallics 15 (8), 1972-1978, 1996 | 116 | 1996 |
| Direct observation of the protonation state of an imino sugar glycosidase inhibitor upon binding A Varrot, CA Tarling, JM Macdonald, RV Stick, DL Zechel, SG Withers, ... Journal of the American Chemical Society 125 (25), 7496-7497, 2003 | 107 | 2003 |
| Anatomy of glycosynthesis: structure and kinetics of the Humicola insolens Cel7B E197A and E197S glycosynthase mutants VMA Ducros, CA Tarling, DL Zechel, AM Brzozowski, TP Frandsen, ... Chemistry & Biology 10 (7), 619-628, 2003 | 87 | 2003 |
| PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon–phosphorus bond FR McSorley, PB Wyatt, A Martinez, EF DeLong, B Hove-Jensen, ... Journal of the American Chemical Society 134 (20), 8364-8367, 2012 | 85 | 2012 |
| Enzymatic synthesis of carbon− fluorine bonds DL Zechel, SP Reid, O Nashiru, C Mayer, D Stoll, DL Jakeman, ... Journal of the American Chemical Society 123 (18), 4350-4351, 2001 | 85 | 2001 |
| Mechanism, mutagenesis, and chemical rescue of a β-mannosidase from Cellulomonas fimi DL Zechel, SP Reid, D Stoll, O Nashiru, RAJ Warren, SG Withers Biochemistry 42 (23), 7195-7204, 2003 | 81 | 2003 |
Steve WithersProfessor of Chemistry and Biochemistry, University Of British ColumbiaVerified email at chem.ubc.ca
