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Thomas Tamsett
Thomas Tamsett
Verified email at novartis.com
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Year
CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
SP Sardi, J Clarke, C Kinnecom, TJ Tamsett, L Li, LM Stanek, MA Passini, ...
Proceedings of the National Academy of Sciences 108 (29), 12101-12106, 2011
3392011
Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies
SP Sardi, J Clarke, C Viel, M Chan, TJ Tamsett, CM Treleaven, J Bu, ...
Proceedings of the National Academy of Sciences 110 (9), 3537-3542, 2013
2852013
Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis
JC Dodge, CM Treleaven, J Pacheco, S Cooper, C Bao, M Abraham, ...
Proceedings of the National Academy of Sciences 112 (26), 8100-8105, 2015
1292015
Metabolic signatures of amyotrophic lateral sclerosis reveal insights into disease pathogenesis
JC Dodge, CM Treleaven, JA Fidler, TJ Tamsett, C Bao, M Searles, ...
Proceedings of the National Academy of Sciences 110 (26), 10812-10817, 2013
1162013
NAD+ activates KNa channels in dorsal root ganglion neurons
TJ Tamsett, KE Picchione, A Bhattacharjee
Journal of Neuroscience 29 (16), 5127-5134, 2009
1042009
Disease progression in a mouse model of amyotrophic lateral sclerosis: the influence of chronic stress and corticosterone
JA Fidler, CM Treleaven, A Frakes, TJ Tamsett, M McCrate, SH Cheng, ...
The FASEB Journal 25 (12), 4369, 2011
392011
Gene transfer to the CNS is efficacious in immune-primed mice harboring physiologically relevant titers of anti-AAV antibodies
CM Treleaven, TJ Tamsett, J Bu, JA Fidler, SP Sardi, GD Hurlbut, ...
Molecular Therapy 20 (9), 1713-1723, 2012
382012
Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion
RJ Ziegler, EA Salegio, JC Dodge, J Bringas, CM Treleaven, SD Bercury, ...
Experimental neurology 231 (2), 261-271, 2011
372011
Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of …
JC Dodge, TJ Tamsett, CM Treleaven, TV Taksir, P Piepenhagen, ...
Alzheimer's Research & Therapy 14 (1), 19, 2022
72022
Comparative analysis of acid sphingomyelinase distribution in the CNS of rats and mice following intracerebroventricular delivery
CM Treleaven, T Tamsett, JA Fidler, TV Taksir, SH Cheng, ...
Plos one 6 (1), e16313, 2011
52011
Structure–Activity Relationship Evaluation of Wasp Toxin β-PMTX Leads to Analogs with Superior Activity for Human Neuronal Sodium Channels
CE Garrison, W Guan, M Kato, T Tamsett, T Patel, Y Sun, TP Pathak
ACS Medicinal Chemistry Letters 11 (3), 353-357, 2019
22019
Sodium activated potassium channels (K (Na)) are modulated by nicotinamide adenine dinucleotide (NAD+) in adult dorsal root ganglion (DRG) neurons
TJ Tamsett
State University of New York at Buffalo, 2008
12008
SAR evaluation of wasp toxin-PMTX leads to analogs with superior efficacy for human neuronal sodium channels
C Garrison, W Guan, M Kato, T Tamsett, T Patel, Y Sun, T Pathak
ACS Medicinal Chemistry Letters, 2019
2019
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