| Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape C Lu, SU Jain, D Hoelper, D Bechet, RC Molden, L Ran, D Murphy, ... Science 352 (6287), 844-849, 2016 | 373 | 2016 |
| H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis AS Harutyunyan, B Krug, H Chen, S Papillon-Cavanagh, M Zeinieh, ... Nature communications 10 (1), 1262, 2019 | 261 | 2019 |
| Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas J Bayliss, P Mukherjee, C Lu, SU Jain, C Chung, D Martinez, B Sabari, ... Science translational medicine 8 (366), 366ra161-366ra161, 2016 | 173 | 2016 |
| PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism SU Jain, TJ Do, PJ Lund, AQ Rashoff, KL Diehl, M Cieslik, A Bajic, ... Nature communications 10 (1), 2146, 2019 | 160 | 2019 |
| Strategy for “detoxification” of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2 ZZ Brown, MM Müller, SU Jain, CD Allis, PW Lewis, TW Muir Journal of the American Chemical Society 136 (39), 13498-13501, 2014 | 103 | 2014 |
| Continued activity of the pioneer factor Zelda is required to drive zygotic genome activation SL McDaniel, TJ Gibson, KN Schulz, MF Garcia, M Nevil, SU Jain, ... Molecular cell 74 (1), 185-195. e4, 2019 | 101 | 2019 |
| H3 K27M and EZHIP impede H3K27-methylation spreading by inhibiting allosterically stimulated PRC2 SU Jain, AQ Rashoff, SD Krabbenhoft, D Hoelper, TJ Do, TJ Gibson, ... Molecular cell 80 (4), 726-735. e7, 2020 | 96 | 2020 |
| Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase KS Jani, SU Jain, EJ Ge, KL Diehl, SM Lundgren, MM Müller, PW Lewis, ... Proceedings of the National Academy of Sciences 116 (17), 8295-8300, 2019 | 88 | 2019 |
| S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3 H Jayaram, D Hoelper, SU Jain, N Cantone, SM Lundgren, F Poy, ... Proceedings of the National Academy of Sciences 113 (22), 6182-6187, 2016 | 77 | 2016 |
| Histone H3. 3 G34 mutations promote aberrant PRC2 activity and drive tumor progression SU Jain, S Khazaei, DM Marchione, SM Lundgren, X Wang, DN Weinberg, ... Proceedings of the National Academy of Sciences 117 (44), 27354-27364, 2020 | 65 | 2020 |
| H3. 3 G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in giant cell tumor of bone S Khazaei, N De Jay, S Deshmukh, LD Hendrikse, W Jawhar, CCL Chen, ... Cancer discovery 10 (12), 1968-1987, 2020 | 53 | 2020 |
| Dysregulation of Polycomb Repressive Complex 2 by Oncogenic Histone Mutations in Pediatric Brain and Bone Tumors S Jain The University of Wisconsin-Madison, 2020 | | 2020 |
