Lei Xi  (席雷)
Lei Xi (席雷)
Associate Professor of Medicine, Virginia Commonwealth University
Подтвержден адрес электронной почты в домене vcuhealth.org - Главная страница
Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis: essential role of nitric oxide signaling
A Das, L Xi, RC Kukreja
Journal of Biological Chemistry 280 (13), 12944-12955, 2005
Sildenafil induces delayed preconditioning through inducible nitric oxide synthase–dependent pathway in mouse heart
F Salloum, C Yin, L Xi, RC Kukreja
Circulation Research 92 (6), 595-597, 2003
Pharmacological preconditioning with sildenafil: basic mechanisms and clinical implications
RC Kukreja, F Salloum, A Das, R Ockaili, C Yin, YA Bremer, PW Fisher, ...
Vascular pharmacology 42 (5-6), 219-232, 2005
Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3β
A Das, L Xi, RC Kukreja
Journal of Biological Chemistry 283 (43), 29572-29585, 2008
Inducible Nitric Oxide Synthase Mediates Delayed Myocardial Protection Induced by Activation of Adenosine A1 Receptors: Evidence From Gene-Knockout Mice
T Zhao, L Xi, J Chelliah, JE Levasseur, RC Kukreja
Circulation 102 (8), 902-907, 2000
Rapamycin confers preconditioning-like protection against ischemia–reperfusion injury in isolated mouse heart and cardiomyocytes
SA Khan, F Salloum, A Das, L Xi, GW Vetrovec, RC Kukreja
Journal of molecular and cellular cardiology 41 (2), 256-264, 2006
Cardioprotection with phosphodiesterase-5 inhibition—a novel preconditioning strategy
RC Kukreja, R Ockaili, F Salloum, C Yin, J Hawkins, A Das, L Xi
Journal of molecular and cellular cardiology 36 (2), 165-173, 2004
PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
A Das, D Durrant, FN Salloum, L Xi, RC Kukreja
Pharmacology & therapeutics 147, 12-21, 2015
Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1α and AP-1 and iNOS signaling
L Xi, M Taher, C Yin, F Salloum, RC Kukreja
American Journal of Physiology-Heart and Circulatory Physiology 287 (6 …, 2004
Hypoxia inducible factor 1 (HIF-1) and cardioprotection
D Tekin, AD Dursun, L Xi
Acta Pharmacologica Sinica 31 (9), 1085-1094, 2010
ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice
A Das, FN Salloum, L Xi, YJ Rao, RC Kukreja
American journal of physiology-heart and circulatory physiology 296 (5 …, 2009
Essential role of inducible nitric oxide synthase in monophosphoryl lipid A–induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice
L Xi, NC Jarrett, ML Hess, RC Kukreja
Circulation 99 (16), 2157-2163, 1999
Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered …
A Das, D Durrant, S Koka, FN Salloum, L Xi, RC Kukreja
Journal of Biological Chemistry 289 (7), 4145-4160, 2014
Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect
S Koka, A Das, SG Zhu, D Durrant, L Xi, RC Kukreja
Journal of Pharmacology and Experimental Therapeutics 334 (3), 1023-1030, 2010
Evidence that NOS2 acts as a trigger and mediator of late preconditioning induced by acute systemic hypoxia
L Xi, D Tekin, E Gursoy, F Salloum, JE Levasseur, RC Kukreja
American Journal of Physiology-Heart and Circulatory Physiology 283 (1), H5-H12, 2002
Dietary nitrate supplementation protects against doxorubicin-induced cardiomyopathy by improving mitochondrial function
SG Zhu, RC Kukreja, A Das, Q Chen, EJ Lesnefsky, L Xi
Journal of the American College of Cardiology 57 (21), 2181-2189, 2011
Loss of Myocardial Ischemic Postconditioning in Adenosine A1 and Bradykinin B2 Receptors Gene Knockout Mice
L Xi, A Das, ZQ Zhao, VF Merino, M Bader, RC Kukreja
Circulation 118 (14_suppl_1), S32-S37, 2008
Opening of Ca2+-activated K+ channels triggers early and delayed preconditioning against I/R injury independent of NOS in mice
X Wang, C Yin, L Xi, RC Kukreja
American Journal of Physiology-Heart and Circulatory Physiology 287 (5 …, 2004
Myocardial preconditioning: basic concepts and potential mechanisms
S Okubo, L Xi, NL Bernardo, K Yoshida, RC Kukreja
Stress Adaptation, Prophylaxis and Treatment, 3-12, 1999
Emerging new uses of phosphodiesterase-5 inhibitors in cardiovascular diseases
RC Kukreja, FN Salloum, A Das, S Koka, RA Ockaili, L Xi
Experimental & Clinical Cardiology 16 (4), e30, 2011
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