| Design, synthesis and selection of DNA-encoded small-molecule libraries MA Clark, RA Acharya, CC Arico-Muendel, SL Belyanskaya, ... Nature chemical biology 5 (9), 647-654, 2009 | 620 | 2009 |
| Pathways for protein disulphide bond formation AR Frand, JW Cuozzo, CA Kaiser Trends in cell biology 10 (5), 203-210, 2000 | 452 | 2000 |
| Competition between glutathione and protein thiols for disulphide-bond formation JW Cuozzo, CA Kaiser Nature cell biology 1 (3), 130-135, 1999 | 397 | 1999 |
| A flavoprotein oxidase defines a new endoplasmic reticulum pathway for biosynthetic disulphide bond formation CS Sevier, JW Cuozzo, A Vala, F Åslund, CA Kaiser Nature cell biology 3 (10), 874-882, 2001 | 235 | 2001 |
| Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3 JS Disch, G Evindar, CH Chiu, CA Blum, H Dai, L Jin, E Schuman, ... Journal of medicinal chemistry 56 (9), 3666-3679, 2013 | 206 | 2013 |
| Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT) H Deng, H O’Keefe, CP Davie, KE Lind, RA Acharya, GJ Franklin, J Larkin, ... Journal of medicinal chemistry 55 (16), 7061-7079, 2012 | 152 | 2012 |
| Machine learning on DNA-encoded libraries: a new paradigm for hit finding K McCloskey, EA Sigel, S Kearnes, L Xue, X Tian, D Moccia, D Gikunju, ... Journal of Medicinal Chemistry 63 (16), 8857-8866, 2020 | 112 | 2020 |
| Encoded library synthesis using chemical ligation and the discovery of sEH inhibitors from a 334-million member library A Litovchick, CE Dumelin, S Habeshian, D Gikunju, MA Guié, P Centrella, ... Scientific reports 5 (1), 10916, 2015 | 103 | 2015 |
| Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood JP Hall, Y Kurdi, S Hsu, J Cuozzo, J Liu, JB Telliez, KJ Seidl, A Winkler, ... Journal of biological chemistry 282 (46), 33295-33304, 2007 | 98 | 2007 |
| Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1 … CS Kollmann, X Bai, CH Tsai, H Yang, KE Lind, SR Skinner, Z Zhu, ... Bioorganic & Medicinal Chemistry 22 (7), 2353-2365, 2014 | 96 | 2014 |
| Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis Y Hu, N Green, LK Gavrin, K Janz, N Kaila, HQ Li, JR Thomason, ... Bioorganic & medicinal chemistry letters 16 (23), 6067-6072, 2006 | 83 | 2006 |
| Discovery of a potent BTK inhibitor with a novel binding mode by using parallel selections with a DNA‐encoded chemical library JW Cuozzo, PA Centrella, D Gikunju, S Habeshian, CD Hupp, AD Keefe, ... ChemBioChem 18 (9), 864-871, 2017 | 78 | 2017 |
| Isoform-selective ATAD2 chemical probe with novel chemical structure and unusual mode of action AE Fernández-Montalván, M Berger, B Kuropka, SJ Koo, V Badock, ... ACS chemical biology 12 (11), 2730-2736, 2017 | 77 | 2017 |
| Novel autotaxin inhibitor for the treatment of idiopathic pulmonary fibrosis: a clinical candidate discovered using DNA-encoded chemistry JW Cuozzo, MA Clark, AD Keefe, A Kohlmann, M Mulvihill, H Ni, ... Journal of Medicinal Chemistry 63 (14), 7840-7856, 2020 | 76 | 2020 |
| Discovery of potent and selective inhibitors for ADAMTS-4 through DNA-encoded library technology (ELT) Y Ding, H O’Keefe, JL DeLorey, DI Israel, JA Messer, CH Chiu, ... ACS Medicinal Chemistry Letters 6 (8), 888-893, 2015 | 75 | 2015 |
| Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor α (TNF-α) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4 … N Green, Y Hu, K Janz, HQ Li, N Kaila, S Guler, J Thomason, ... Journal of medicinal chemistry 50 (19), 4728-4745, 2007 | 74 | 2007 |
| Structure based design of non-natural peptidic macrocyclic Mcl-1 inhibitors JW Johannes, S Bates, C Beigie, MA Belmonte, J Breen, S Cao, ... ACS medicinal chemistry letters 8 (2), 239-244, 2017 | 72 | 2017 |
| Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling PL Channavajhala, L Wu, JW Cuozzo, JP Hall, W Liu, LL Lin, Y Zhang Journal of Biological Chemistry 278 (47), 47089-47097, 2003 | 72 | 2003 |
| Discovery of a potent class of PI3Kα inhibitors with unique binding mode via encoded library technology (ELT) H Yang, PF Medeiros, K Raha, P Elkins, KE Lind, R Lehr, ND Adams, ... ACS medicinal chemistry letters 6 (5), 531-536, 2015 | 71 | 2015 |
| Lysine-based structure responsible for selective mannose phosphorylation of cathepsin D and cathepsin L defines a common structural motif for lysosomal enzyme targeting JW Cuozzo, K Tao, M Cygler, JS Mort, GG Sahagian Journal of Biological Chemistry 273 (33), 21067-21076, 1998 | 69 | 1998 |
Anthony D KeefeSenior Vice-President of Innovation, X-Chem Inc.Verified email at x-chemrx.com
