Izidor Sosič
Izidor Sosič
Research Scientist, Faculty of Pharmacy, University of Ljubljana
Verified email at ffa.uni-lj.si - Homepage
Title
Cited by
Cited by
Year
Structural characterization and biological evaluation of a clioquinol–ruthenium complex with copper-independent antileukaemic activity
M Gobec, J Kljun, I Sosič, I Mlinarič-Raščan, M Uršič, S Gobec, I Turel
Dalton Transactions 43 (24), 9045-9051, 2014
832014
Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds
B Mirković, M Renko, S Turk, I Sosič, Z Jevnikar, N Obermajer, D Turk, ...
ChemMedChem 6 (8), 1351-1356, 2011
792011
Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F
M Hrast, I Sosič, R Šink, S Gobec
Bioorganic chemistry 55, 2-15, 2014
712014
Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure–activity relationships of nitroxoline derivatives
I Sosič, B Mirkovic, K Arenz, B Stefane, J Kos, S Gobec
Journal of medicinal chemistry 56 (2), 521-533, 2013
672013
Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis
R Sink, I Sosic, M Živec, R Fernandez-Menendez, S Turk, S Pajk, ...
Journal of medicinal chemistry 58 (2), 613-624, 2015
622015
Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity
B Mirković, B Markelc, M Butinar, A Mitrović, I Sosič, S Gobec, O Vasiljeva, ...
Oncotarget 6 (22), 19027, 2015
552015
Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents
D Knez, B Brus, N Coquelle, I Sosič, R Šink, X Brazzolotto, J Mravljak, ...
Bioorganic & medicinal chemistry 23 (15), 4442-4452, 2015
492015
Antibacterial and β‐lactamase inhibitory activity of monocyclic β‐Lactams
L Decuyper, M Jukič, I Sosič, A Žula, M D'hooghe, S Gobec
Medicinal research reviews 38 (2), 426-503, 2018
442018
Nonpeptidic selective inhibitors of the chymotrypsin‐like (β5 i) subunit of the immunoproteasome
I Sosič, M Gobec, B Brus, D Knez, M Živec, J Konc, S Lešnik, M Ogrizek, ...
Angewandte Chemie International Edition 55 (19), 5745-5748, 2016
442016
A new ‘golden age’for the antitubercular target InhA
K Rožman, I Sosič, R Fernandez, RJ Young, A Mendoza, S Gobec, ...
Drug discovery today 22 (3), 492-502, 2017
422017
New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria
S Turk, O Verlaine, T Gerards, M Živec, J Humljan, I Sosič, A Amoroso, ...
Plos one 6 (5), e19418, 2011
422011
Structure–activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF
M Hrast, S Turk, I Sosič, D Knez, CP Randall, H Barreteau, ...
European journal of medicinal chemistry 66, 32-45, 2013
412013
Clioquinol–ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity
A Mitrović, J Kljun, I Sosič, S Gobec, I Turel, J Kos
Dalton Transactions 45 (42), 16913-16921, 2016
402016
Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid
I Sosič, H Barreteau, M Simčič, R Šink, J Cesar, A Zega, SG Grdadolnik, ...
European journal of medicinal chemistry 46 (7), 2880-2894, 2011
362011
4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding site
B Pogorelčnik, M Janežič, I Sosič, S Gobec, T Solmajer, A Perdih
Bioorganic & medicinal chemistry 23 (15), 4218-4229, 2015
352015
New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold
S Pajk, M Živec, R Šink, I Sosič, M Neu, C Chung, M Martínez-Hoyos, ...
European journal of medicinal chemistry 112, 252-257, 2016
342016
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
C Steinebach, YLD Ng, I Sosič, CS Lee, S Chen, S Lindner, LP Vu, ...
Chemical science 11 (13), 3474-3486, 2020
292020
Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion
A Mitrović, B Mirković, I Sosič, S Gobec, J Kos
Biological chemistry 397 (2), 165-174, 2016
262016
Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety
B Mirković, I Sosič, S Gobec, J Kos
PLoS One 6 (11), e27197, 2011
262011
Synthesis of aminoboronic acid derivatives: an update on recent advances
A Šterman, I Sosič, S Gobec, Z Časar
Organic Chemistry Frontiers 6 (16), 2991-2998, 2019
242019
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Articles 1–20