Подписаться
Beata Flachner
Beata Flachner
institute of enzymology, targetex,
Подтвержден адрес электронной почты в домене ttk.mta.hu
Название
Процитировано
Процитировано
Год
Role of phosphate chain mobility of MgATP in completing the 3-phosphoglycerate kinase catalytic site: binding, kinetic, and crystallographic studies with ATP and MgATP
B Flachner, Z Kovári, A Varga, Z Gugolya, F Vonderviszt, G Náray-Szabó, ...
Biochemistry 43 (12), 3436-3449, 2004
582004
Inhibition of c-Met with the specific small molecule tyrosine kinase inhibitor SU11274 decreases growth and metastasis formation of experimental human melanoma
I Kenessey, M Keszthelyi, Z Kramer, J Berta, A Adám, J Dobos, M Mildner, ...
Current cancer drug targets 10 (3), 332-342, 2010
482010
Substrate-induced double sided H-bond network as a means of domain closure in 3-phosphoglycerate kinase
A Varga, B Flachner, P Konarev, É Gráczer, J Szabó, D Svergun, ...
FEBS letters 580 (11), 2698-2706, 2006
362006
Crystallographic and thiol-reactivity studies on the complex of pig muscle phosphoglycerate kinase with ATP analogues: correlation between nucleotide binding mode and helix …
Z Kovári, B Flachner, G Náray-Szabó, M Vas
Biochemistry 41 (28), 8796-8806, 2002
342002
Substrate-assisted movement of the catalytic Lys 215 during domain closure: site-directed mutagenesis studies of human 3-phosphoglycerate kinase
B Flachner, A Varga, J Szabó, L Barna, I Hajdú, G Gyimesi, P Závodszky, ...
Biochemistry 44 (51), 16853-16865, 2005
332005
Target identification and polypharmacology of nutraceuticals
G Dormán, B Flachner, I Hajdú, C András
Nutraceuticals, 315-343, 2021
322021
Correlation between conformational stability of the ternary enzyme–substrate complex and domain closure of 3‐phosphoglycerate kinase
A Varga, B Flachner, E Graczer, S Osváth, AN Szilagyi, M Vas
The FEBS journal 272 (8), 1867-1885, 2005
322005
Communication between the nucleotide site and the main molecular hinge of 3-phosphoglycerate kinase
J Szabó, A Varga, B Flachner, PV Konarev, DI Svergun, P Závodszky, ...
Biochemistry 47 (26), 6735-6744, 2008
312008
Stabilization of β-glucosidase in Aspergillus phoenicis QM 329 pellets
B Flachner, A Brumbauer, K Reczey
Enzyme and microbial technology 24 (5-6), 362-367, 1999
301999
Combination of 2D/3D ligand-based similarity search in rapid virtual screening from multimillion compound repositories. Selection and biological evaluation of potential PDE4 …
K Dobi, I Hajdú, B Flachner, G Fabó, M Szaszkó, M Bognár, C Magyar, ...
Molecules 19 (6), 7008-7039, 2014
252014
Nucleotide binding to pig muscle 3-phosphoglycerate kinase in the crystal and in solution: relationship between substrate antagonism and interdomain communication
A Merli, AN Szilágyi, B Flachner, GL Rossi, M Vas
Biochemistry 41 (1), 111-119, 2002
242002
A chemocentric approach to the identification of cancer targets
B Flachner, Z Lörincz, A Carotti, O Nicolotti, P Kuchipudi, N Remez, ...
PLoS One 7 (4), e35582, 2012
232012
Structure-based consensus scoring scheme for selecting class A aminergic GPCR fragments
ÁA Kelemen, R Kiss, GG Ferenczy, L Kovács, B Flachner, Z Lorincz, ...
Journal of Chemical Information and Modeling 56 (2), 412-422, 2016
172016
Interaction of human 3-phosphoglycerate kinase with L-ADP, the mirror image of D-ADP
A Varga, J Szabó, B Flachner, B Roy, P Konarev, D Svergun, P Závodszky, ...
Biochemical and biophysical research communications 366 (4), 994-1000, 2008
172008
Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening
M Szaszkó, I Hajdú, B Flachner, K Dobi, C Magyar, I Simon, Z Lőrincz, ...
Molecular diversity 21 (1), 175-186, 2017
142017
Thermodynamic analysis of substrate induced domain closure of 3-phosphoglycerate kinase
A Varga, J Szabó, B Flachner, Z Gugolya, F Vonderviszt, P Závodszky, ...
FEBS letters 583 (22), 3660-3664, 2009
132009
Design and selection of novel C1s inhibitors by in silico and in vitro approaches
K Szilágyi, I Hajdú, B Flachner, Z Lőrincz, J Balczer, P Gál, P Závodszky, ...
Molecules 24 (20), 3641, 2019
112019
Dual inhibitors of AChE and BACE-1 for reducing Aβ in Alzheimer’s disease: From in silico to in vivo
N Stern, A Gacs, E Tátrai, B Flachner, I Hajdú, K Dobi, I Bágyi, G Dormán, ...
International Journal of Molecular Sciences 23 (21), 13098, 2022
102022
Role of side-chains in the operation of the main molecular hinge of 3-phosphoglycerate kinase
J Szabó, A Varga, B Flachner, PV Konarev, DI Svergun, P Závodszky, ...
FEBS letters 582 (9), 1335-1340, 2008
102008
Rapid identification of potential drug candidates from multi-million compounds’ repositories. combination of 2D similarity search with 3D ligand/structure based methods and in …
K Szilágyi, B Flachner, I Hajdú, M Szaszkó, K Dobi, Z Lőrincz, S Cseh, ...
Molecules 26 (18), 5593, 2021
92021
В данный момент система не может выполнить эту операцию. Повторите попытку позднее.
Статьи 1–20